A novel dual-wavelength laser stimulator to elicit transient and tonic nociceptive stimulation

Lasers in Medical Science
Xiao-Xi DongYing-Xin Li

Abstract

This study aimed to develop a new laser stimulator to elicit both transient and sustained heat stimulation with a dual-wavelength laser system as a tool for the investigation of both transient and tonic experimental models of pain. The laser stimulator used a 980-nm pulsed laser to generate transient heat stimulation and a 1940-nm continuous-wave (CW) laser to provide sustained heat stimulation. The laser with 980-nm wavelength can elicit transient pain with less thermal injury, while the 1940-nm CW laser can effectively stimulate both superficial and deep nociceptors to elicit tonic pain. A proportional integral-derivative (PID) temperature feedback control system was implemented to ensure constancy of temperature during heat stimulation. The performance of this stimulator was evaluated by in vitro and in vivo animal experiments. In vitro experiments on totally 120 specimens fresh pig skin included transient heat stimulation by 980-nm laser (1.5 J, 10 ms), sustained heat stimulation by 1940-nm laser (50-55 °C temperature control mode or 1.5 W, 5 min continuous power supply), and the combination of transient/sustained heat stimulation by dual lasers (1.5 J, 10 ms, 980-nm pulse laser, and 1940-nm laser with 50-55 °C temperature ...Continue Reading

References

Jun 1, 1979·Pain·J J Bonica
Mar 23, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J SpiegelR D Treede
Apr 11, 2001·Lasers in Surgery and Medicine·M GülsoyI Cilesiz
Sep 15, 2001·Nature·D Julius, A I Basbaum
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Arendt-Nielsen, A C N Chen
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Plaghki, A Mouraux
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·Rolf-Detlef TreedeUlf Baumgärtner
Jul 3, 2007·Photomedicine and Laser Surgery·U OronJ Streeter
May 20, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G CruccuL Garcia-Larrea
Sep 21, 2010·Pain·Maija HaanpääRolf-Detlef Treede
Oct 19, 2010·The Journal of Pharmacology and Experimental Therapeutics·Nian GongYong-Xiang Wang
Dec 21, 2010·The Journal of Pain : Official Journal of the American Pain Society·Meyke RoosinkMaarten J Ijzerman
Jan 29, 2011·Lasers in Medical Science·Khalid M AlGhamdiNoura A Moussa
Oct 9, 2012·Neurophysiologie clinique = Clinical neurophysiology·J-M Guérit
Jan 22, 2013·Lasers in Medical Science·Ladan EslamianReza Fekrazad
Oct 10, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Claudia M CampbellMichael T Smith
Apr 16, 2014·Lasers in Medical Science·Hassan SoleimanpourAfshin Iranpour
May 8, 2014·Lasers in Medical Science·J A RuaroR A Nicolau
Sep 23, 2014·Lasers in Medical Science·Alessandra Rossi PaolilloVanderlei Salvador Bagnato
Sep 27, 2014·Lasers in Medical Science·F J LiY Guo
Nov 15, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Joshua Wellington
Feb 20, 2015·PloS One·Christopher SinkeUlrike Bingel
Dec 9, 2015·The Journal of Headache and Pain·Mieszko WieckiewiczAnna Paradowska-Stolarz
Mar 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Judith A E M ZechaRené-Jean Bensadoun
May 22, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Gregory GlazovJon Emery
Aug 1, 2016·Journal of Photochemistry and Photobiology. B, Biology·Ali Borzabadi-Farahani
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Ana Laura Martins de AndradeNivaldo Antônio Parizotto

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