A Novel Dynamic Model for Health Economic Analysis of Influenza Vaccination in the Elderly

Infectious Diseases and Therapy
Mark MullikinEckhardt Petri

Abstract

New vaccines are being developed to improve the efficacy of seasonal influenza immunization in elderly persons aged ≥65 years. These products require clinical and economic evaluation to aid policy decisions. To address this need, a two-part model has been developed, which we have applied to examine the potential clinical and economic impact of vaccinating elderly persons with adjuvanted trivalent inactivated influenza vaccine (aTIV) relative to conventional trivalent (TIV) and quadrivalent (QIV) vaccines. We compared outcomes in the US population for (1) aTIV in persons aged ≥65 years and QIV in all other age cohorts; (2) QIV in all cohorts; (3) TIV in all cohorts. Low, average, and high intensity seasons with low, average, and high vaccine match scenarios were compared. Probabilistic sensitivity analysis was conducted within each discrete scenario to explore the impact of variation in model inputs on potential outcomes. Assuming current vaccination coverage rates in the US population with (a) 25% better efficacy of adjuvanted versus non-adjuvanted vaccine against any strain and (b) 35% better efficacy of non-adjuvanted vaccine against matched B versus mismatched B strains, use of aTIV in persons aged ≥65 years and QIV in perso...Continue Reading

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Citations

Dec 8, 2016·Human Vaccines & Immunotherapeutics·Núria TornerUNKNOWN Working Group of the Project PI12/02079
Jun 15, 2017·Expert Review of Pharmacoeconomics & Outcomes Research·Pieter T de BoerMaarten J Postma
Mar 3, 2018·Influenza and Other Respiratory Viruses·Donatella PanattoDaniela Amicizia
Feb 10, 2018·Human Vaccines & Immunotherapeutics·Stefano CapriDonatella Panatto
Feb 9, 2019·Human Vaccines & Immunotherapeutics·Ilaria LopertoMaria Triassi
Apr 1, 2019·European Journal of Public Health·Chiara de WaureRoberto Gasparini
May 24, 2017·Human Vaccines & Immunotherapeutics·Riju RayRafik Bekkat-Berkani

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