A novel electrode array for diameter-dependent control of axonal excitability: a simulation study

IEEE Transactions on Bio-medical Engineering
Zeng Lertmanorat, D M Durand

Abstract

Electrical extracellular stimulation of peripheral nerve activates the large-diameter motor fibers before the small ones, a recruitment order opposite the physiological recruitment of myelinated motor fibers during voluntary muscle contraction. Current methods to solve this problem require a long-duration stimulus pulse which could lead to electrode corrosion and nerve damage. The hypothesis that the excitability of specific diameter fibers can be suppressed by reshaping the profile of extracellular potential along the axon using multiple electrodes is tested using computer simulations in two different volume conductors. Simulations in a homogenous medium with a nine-contact electrode array show that the current excitation threshold (Ith) of large diameter axons (13-17 microm) (0.6-3.0 mA) is higher than that of small-diameter axons (2-7 microm) (0.4-0.7 mA) with 200-microm axon-electrode distance and 10-micros stimulus pulse. The electrode array is also tested in a three-dimensional finite-element model of the sacral root model of dog (ventral root of S3). A single cathode activates large-diameter axons before activating small axons. However, a nine-electrode array activates 50% of small axons while recruiting only 10% of larg...Continue Reading

References

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Citations

Feb 3, 2006·Annals of Biomedical Engineering·Zeng LertmanoratDominique M Durand
Jul 14, 2011·Journal of Neural Engineering·E J PetersonD J Tyler
Jun 19, 2014·Biological cybernetics·Hyun-Joo Park, Dominique M Durand
Nov 1, 2011·Journal of Physiology, Paris·Sébastien Joucla, Blaise Yvert
Feb 1, 2019·Journal of Neural Engineering·Alessio Paolo BuccinoAslak Tveito
Apr 12, 2011·Journal of Neural Engineering·Christopher R ButsonGregory A Clark
May 7, 2005·Journal of Neural Engineering·Zeng Lertmanorat, Dominique M Durand
Nov 20, 2019·Journal of Neuroscience Methods·Christopher E Larson, Ellis Meng

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