PMID: 16617612Apr 19, 2006Paper

A novel evolutionary drug scheduling model in cancer chemotherapy

IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society
Yong LiangTony Shu Kam Mok

Abstract

In this paper, we introduce a modified optimal control model of drug scheduling in cancer chemotherapy and a new adaptive elitist-population-based genetic algorithm (AEGA) to solve it. Working closely with an oncologist, we first modify the existing model, because its equation for the cumulative drug toxicity is inconsistent with medical knowledge and clinical experience. To explore multiple efficient drug scheduling policies, we propose a novel variable representation--a cycle-wise representation, and modify the elitist genetic search operators in the AEGA. The simulation results obtained by the modified model match well with the clinical treatment experiences, and can provide multiple efficient solutions for oncologists to consider. Moreover, it has been shown that the evolutionary drug scheduling approach is simple, and capable of solving complex cancer chemotherapy problems by adapting multimodal versions of evolutionary algorithms.

References

Jan 1, 1991·Cancer Chemotherapy and Pharmacology·H Parry, K Martin
May 29, 2002·Artificial Intelligence in Medicine·K C TanT H Lee
Nov 25, 2003·Evolutionary Computation·Lino Costa, Pedro Oliveira
Apr 19, 2006·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Yong LiangTony Shu Kam Mok

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Citations

Oct 5, 2010·Medical & Biological Engineering & Computing·S AlgoulM A A Majumder
Sep 7, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tony S K MokKwok-Chi Lam
Mar 15, 2013·Journal of Theoretical Biology·M Carmen CalzadaMercedes Marín
Jul 14, 2010·Artificial Intelligence in Medicine·Minaya VillasanaSoraya Aguilar
Apr 19, 2006·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Yong LiangTony Shu Kam Mok
Feb 7, 2007·IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society·Sui-Man TseTony Shu-kam Mok
Jul 7, 2015·Journal of Biomedical Informatics·Jianxu ZhuZan Shen
Mar 14, 2018·IET Systems Biology·Ehsan ShakeriAmir Esmaeili Abharian
Jan 16, 2021·Drug Delivery and Translational Research·Richa SharmaDeepak Joshi
Mar 23, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Bharti PanjwaniVijay Mohan

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