A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells

Oncotarget
Shogo SengaHiroshi Fujii

Abstract

Epidermal or cutaneous fatty acid-binding protein is an intracellular lipid-binding protein, also known as FABP5, and its expression level is closely related to cancer cell proliferation and metastatic activities in various types of carcinoma. However, the molecular mechanisms of FABP5 in cancer cell proliferation and its other functions have remained unclear. In the present study, we have clearly revealed that FABP5 activated expression of metabolic genes (ATP5B, LCHAD, ACO2, FH and MFN2) via a novel signaling pathway in an ERRα (estrogen-related receptor α)-dependent manner in prostate cancer cell lines. To clarify the novel function of FABP5, we examined the activation mechanisms of the ERRα target genes via FABP5. A direct protein-protein interaction between FABP5 and ERRα was demonstrated by immunoprecipitation and GST pull-down assays. We have clearly revealed that FABP5 interacted directly with transcriptional complex containing ERRα and its co-activator PGC-1β to increase expression of the ERRα target genes. In addition, we have shown that FABP5 knockdown induced high energy stress leading to induction of apoptosis and cell cycle arrest via AMPK-FOXO3A signaling pathway in prostate cancer cells, suggesting that FABP5 pl...Continue Reading

References

Aug 28, 1998·Science·D R Green, J C Reed
Mar 10, 1999·Journal of the National Cancer Institute·L N KolonelR V Cooney
May 18, 2001·The Journal of Biological Chemistry·S ChenM Sherman
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Jun 27, 2002·Biochimica Et Biophysica Acta·Debabrata BanerjeeJoseph R Bertino
Sep 12, 2002·Cellular and Molecular Life Sciences : CMLS·A W Zimmerman, J H Veerkamp
Feb 24, 1956·Science·O WARBURG
Apr 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sylvia N SchreiberAnastasia Kralli
Jul 3, 2004·Cancer Research·Takashi SuzukiHironobu Sasano
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·C P CheungFranky L Chan
Mar 22, 2005·Biochimica Et Biophysica Acta·Paul Targett-AdamsJohn McLauchlan
Feb 13, 2007·International Journal of Cancer. Journal International Du Cancer·Tetsuya FujimuraSatoshi Inoue
May 19, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Jiro FujimotoTeruhiko Tamaya
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Apr 26, 2008·Annual Review of Nutrition·Judith Storch, Betina Corsico
Aug 14, 2008·Nucleic Acids Research·Catherine TeyssierJean-Marc Vanacker
Sep 10, 2008·Trends in Endocrinology and Metabolism : TEM·Josep A Villena, Anastasia Kralli
Mar 2, 2010·Cell Cycle·Fulvio Chiacchiera, Cristiano Simone
Aug 19, 2010·The Journal of Biological Chemistry·Judith Storch, Alfred E Thumser
Jan 5, 2011·Nature Reviews. Endocrinology·Larry J SuvaRobert J Griffin
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 19, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Stéphanie BiancoJean-Marc Vanacker
Apr 21, 2011·Human Genomics·Rebecca L Smathers, Dennis R Petersen
Jun 16, 2011·The Journal of International Medical Research·R ChenY Xu
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 17, 2012·Prostaglandins & Other Lipid Mediators·Janel Suburu, Yong Q Chen
Sep 25, 2012·Nature Reviews. Cancer·Douglas C Wallace
Dec 5, 2012·Oncogene·G DebloisV Giguère
Mar 1, 2013·Nature Reviews. Cancer·Arkaitz CarracedoPier Paolo Pandolfi
Apr 9, 2013·Biochimica Et Biophysica Acta·Giorgia ZadraMassimo Loda

❮ Previous
Next ❯

Citations

Jan 19, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jie MaXuejun Zhang
Sep 11, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Heli XuJudith Storch
Jun 15, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wellerson R ScaranoLemos Bernardo
Dec 14, 2019·Scientific Reports·Gregory CarbonettiMartin Kaczocha
May 21, 2019·Frontiers in Cellular Neuroscience·Lisandro Jorge Falomir-LockhartAndrés Martín Toscani
Oct 12, 2019·Journal of Cellular Physiology·Guangzhen WuQifei Wang
Jan 13, 2021·Seminars in Cancer Biology·Alfonso Varela-LópezJosé L Quiles
Aug 14, 2021·Frontiers in Oncology·Natalia ScagliaGiorgia Zadra
Nov 7, 2021·Cancer Metastasis Reviews·Gioia HeraviWanqing Liu
Nov 20, 2021·Archives of Gynecology and Obstetrics·Weiyi HuangPengming Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
pull-down
Immunoprecipitation
flow cytometry
PCR
confocal microscopy
Assay
scraping
ChIP

Software Mentioned

GraphPad Prism
CellQuest
GraphPad

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.