A novel form of non-X-linked hyperigm associated with growth and pubertal disturbances and with lymphoma development.

The Journal of Pediatrics
Viviana MoscheseA Durandy

Abstract

HyperIgM syndrome is a heterogenous immunodeficiency characterized by impaired class-switch recombination due to different molecular abnormalities. We report on two female patients affected by a novel syndrome associating HIGM, growth and pubertal disturbances, and severe lymphoid hyperplasia with eventual development into lymphomas, suggesting a DNA repair defect.

References

Sep 23, 2003·Current Opinion in Immunology·Jean-Pierre de VillartayIsabelle Villey

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Citations

Mar 21, 2020·Journal of Clinical Medicine·Vera GalloClaudio Pignata

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