A novel function of insulin in rat dermis

The Journal of Physiology
Torbjørn NedrebøR K Reed

Abstract

In this study we present a novel function of insulin in rat dermis. We investigated local effects of insulin on interstitial fluid pressure (Pif), and capillary albumin leakage and pro-inflammatory cytokine production in skin and serum after intravenous lipopolysaccharide (LPS), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) challenge treated with a glucose-insulin-potassium regimen (GIK). The main objective for this study was to investigate anti-inflammatory effects of insulin. Work by others shows that insulin stimulates cell adhesion, and that this effect is dependent upon phosphatidylinositol 3-kinase (PI3K) activity. Cytokines like platelet-derived growth factor BB (PDGF-BB) attenuate lowering of Pif, possibly via PI3K. LPS and pro-inflammatory cytokines contribute to oedema development during acute inflammation by lowering the Pif. Intravenous injection of LPS, TNF-alpha or IL-1beta to Wistar Møller rats caused a lowering of Pif, but after local injection of insulin in the paw, Pif increased back to control values. IL-1beta caused a lowering in control from -0.5 +/- 0.2 mmHg to -3.0 +/- 0.2 mmHg after 20 min (mean +/- S.E.M.) (P < 0.05). Within 50 min after insulin injection the pressure was inc...Continue Reading

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Citations

Nov 23, 2006·Infection and Immunity·Mahalia S DesruisseauxPhilipp E Scherer
Jun 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Oyvind Sverre SvendsenRolf K Reed
Jul 15, 2009·Journal of Molecular and Cellular Cardiology·Rolf K ReedKristofer Rubin
Feb 19, 2008·Archives of Oral Biology·Elif Eser SakallioğluIlker Keskiner
Jan 13, 2015·Cryobiology·Hege K BrekkePaul Husby
Sep 5, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Ø S SvendsenH Wiig
Aug 23, 2017·Scientific Reports·Vahid ReyhaniKristofer Rubin
Dec 1, 2020·Frontiers in Veterinary Science·Randolph H Stewart

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