A novel function of mtDNA: its involvement in metastasis

Annals of the New York Academy of Sciences
Kaori Ishikawa, Jun-Ichi Hayashi

Abstract

It has been controversial whether mtDNA mutations are responsible for oncogenic transformation (normal cells to develop tumors) and for malignant progression (tumor cells to develop metastases). To clarify this issue, we created transmitochondrial cybrids with mtDNA exchanged between mouse tumor cells that express different metastatic phenotypes. The G13997A mutation in the ND6 gene of mtDNA from high-metastatic tumor cells reversibly controlled development of metastases by overproduction of reactive oxygen species (ROS). The mtDNA-mediated reversible control of metastasis reveals a novel function of mtDNA, and suggests that ROS scavengers may be therapeutically effective in suppressing metastasis.

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KanedaH Yonekawa
Nov 7, 1998·Nature Genetics·K PolyakB Vogelstein
Mar 5, 1999·Science·D C Wallace
Nov 5, 2003·The Journal of Clinical Investigation·Robert W TaylorDouglass M Turnbull
Jan 18, 2005·Biochemical and Biophysical Research Communications·Miho AkimotoJun-Ichi Hayashi
Apr 5, 2008·Science·Kaori IshikawaJun-Ichi Hayashi

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Citations

Jul 19, 2011·Trends in Molecular Medicine·Nuno RaimundoGerald S Shadel
Jun 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Luiza F de AraujoWilson A Silva
Nov 29, 2011·International Journal of Cancer. Journal International Du Cancer·Sang Woo LimMyung Geun Shin
Jan 5, 2014·Acta Neuropathologica Communications·Ka Yu YeungJustin C St John
Jun 28, 2015·BMC Research Notes·Asan Meera Sahib Haja MohideenSevtap Savas
Dec 3, 2014·Brain Research·Adam NagyBernadette Kalman
Dec 29, 2015·Annals of Laboratory Medicine·Min-Gu KangMyung-Geun Shin
Dec 5, 2019·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Mohammad Mehdi JahaniMassoud Houshmand
Jan 24, 2013·International Journal of Oncology·Kristina S LehnusQian An
Dec 14, 2018·Cancer Metastasis Reviews·Thomas C BeadnellDanny R Welch
Sep 6, 2019·Cancer Research·Timothy C KennyDoris Germain
Jul 25, 2021·International Journal of Molecular Sciences·Carlos Jhovani Pérez-AmadoSilvia Jiménez-Morales

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