A novel furanone-modified antibacterial dental glass ionomer cement

Acta Biomaterialia
Yiming WengDong Xie

Abstract

A novel furanone derivative and a polyacid constructed from it were synthesized, characterized and formulated into experimental high strength cements. The compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements. The effect of human saliva and aging were investigated. The antibacterial activity against Lactobacillus sp. and cytotoxicity to human pulp cells were also evaluated. The results show that all the formulated furanone-containing cements showed antibacterial activity, with an initial reduction in CS. The effect of the furanone derivative loading was significant. Increasing loading enhanced the antibacterial activity but reduced the initial CS of the formed cements. The derivative showed antibacterial activity against both S. mutans and Lactobacillus sp. Human saliva did not affect the antibacterial activity of the cement. The cytotoxicity study with human dental pulp cells shows that the furanone-modified cement was biocompatible. A 30 day aging study indicated that the cements may have long-lasting antibacterial activity. Within the limitations of this study it appears that the experimental cement could be a clinically attractive...Continue Reading

References

Jun 1, 1995·Journal of Dentistry·S ImazatoJ F McCabe
Jul 1, 1996·Dental Materials : Official Publication of the Academy of Dental Materials·K YamamotoJ Yamauchi
Sep 14, 1999·Dental Materials : Official Publication of the Academy of Dental Materials·M A Cattani-LorenteJ M Meyer
May 10, 2000·Clinical Oral Investigations·J C WatahaD J Mettenburg
Jun 19, 2001·Primary Dental Care : Journal of the Faculty of General Dental Practitioners (UK)·V DeligeorgiN H Wilson
Sep 25, 2001·Dental Materials : Official Publication of the Academy of Dental Materials·N EbiS Ebisu
Mar 21, 2002·Acta Odontologica Scandinavica·Ivar A MjörJacquelyn E Moorhead
May 15, 2002·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Craig Kirkham Naylor
May 17, 2002·Dental Clinics of North America·Juergen ManhartReinhard Hickel
Mar 12, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·Prudencio W R OsinagaAntonio Muench
Jun 18, 2003·Biomaterials·Satoshi ImazatoRoy R B Russell
Jun 17, 2004·Acta Odontologica Scandinavica·Helena Forss, Eeva Widström
Feb 3, 2005·Bioorganic & Medicinal Chemistry Letters·Eric LattmannNison Sattayasai
Oct 18, 2005·Dental Materials : Official Publication of the Academy of Dental Materials·Yusuke TakahashiFranklin R Tay
Apr 18, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·Annette WiegandThomas Attin
Jun 24, 2008·European Journal of Medicinal Chemistry·Pascal ThebaultSerge Géribaldi
May 2, 2009·Journal of Dental Research·F LiJ H Chen
Mar 11, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Dong XieCunge Zheng

❮ Previous
Next ❯

Citations

Aug 29, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Miguel M LinoLino S Ferreira
Jan 1, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Zhejun WangMarkus Haapasalo
Jul 1, 2016·International Journal of Oral Science·Su-Ping WangLei Cheng
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Juan F D MonteroJúlio C M Souza
Jan 29, 2019·Journal of Biomaterials Science. Polymer Edition·Xin WenDong Xie
Mar 8, 2019·Journal of Biomaterials Applications·Rashed AlmouseDong Xie
Aug 19, 2020·Journal of Biomaterials Science. Polymer Edition·Yong ChenDong Xie
Mar 6, 2018·Frontiers in Physiology·Xanthippi ChatzistavrouPetros Papagerakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

European Journal of Oral Sciences
Yiming WengDong Xie
Journal of Materials Science. Materials in Medicine
Yiming WengDong Xie
Dental Materials : Official Publication of the Academy of Dental Materials
Dong XieCunge Zheng
Dental Materials : Official Publication of the Academy of Dental Materials
Catherine FanKyumin Whang
Clinical Oral Investigations
Ralf BürgersSebastian Hahnel
© 2021 Meta ULC. All rights reserved