A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance

Human Pathology
Yuki KumaYoshinao Oda

Abstract

Hidradenoma usually presents as a solitary, slow-growing, and solid or cystic nodular lesion, which arises in various anatomical sites. Its diagnosis is occasionally difficult because the tumor shares histological features with other cutaneous appendage tumors. Recently, CRTC1-MAML2 fusion gene was reported in hidradenomas, with the fusion transcript being demonstrated in approximately 50% of cases. However, limited information is available regarding its clinical significance. Here, we investigated the relationship between the fusion gene and clinicohistopathological features. We reviewed 39 cases histologically diagnosed as hidradenoma. Reverse-transcription polymerase chain reaction (RT-PCR) was performed for all 39 cases, and fluorescence in situ hybridization was also performed for the RT-PCR-negative cases. The 39 tumors included 36 clear cell hidradenomas and 3 poroid hidradenomas. The details of the cellular components were as follows: clear cell-dominant type, 9 cases; polygonal cell-dominant type, 21 cases; and equally mixed type, 9 cases. There were no tumors with apparent mucinous cells. There were 8 tumors with prominent cystic change, 2 of which presented apocrine-like decapitated secretion. CRTC1-MAML2 fusion was ...Continue Reading

Citations

Dec 27, 2019·The American Journal of Surgical Pathology·Katharina WiedemeyerThomas Brenn
Apr 10, 2020·The American Journal of Dermatopathology·Andrea Saggini, Laura Held
Dec 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·May P ChanPaul W Harms
Oct 28, 2019·Bioscience Reports·Ming ZhangYuan Wu
Jan 7, 2021·Advances in Anatomic Pathology·M Hasan Toper, Sulen Sarioglu
May 24, 2021·Surgical Pathology Clinics·Grace Hile, Paul W Harms
Mar 20, 2021·The American Journal of Surgical Pathology·Nicolas MacagnoMaxime Battistella
Aug 20, 2021·The American Journal of Dermatopathology·Pedro ZaballosLuis Requena
Jul 11, 2020·Annales de pathologie·Maxime Battistella
Jul 2, 2021·Histopathology·Jaclyn M PlotzkePaul W Harms

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