A novel fusionless vertebral physeal device inducing spinal growth modulation for the correction of spinal deformities.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Eliane C SchmidStefan Parent

Abstract

Current fusionless scoliosis surgical techniques span the intervertebral disc. This alters the spine stiffness, disc pressure equilibrium and possibly may lead to disc degeneration. A new fusionless physeal device was developed that locally modulates vertebral growth by compressing the physeal ring, while maintaining maximum segmental spinal mobility without spanning the intervertebral disc. This study's objective was to test the feasibility of the device on a small animal model by inducing a scoliotic deformity (inverse approach) while analyzing the growth modifications. This study was conducted on caudal vertebrae of 21 rats (26-day-old) divided into 3 groups: (1) "experimental" (n = 11) with 4 instrumented vertebrae, (2) sham (n = 5) and (3) control (n = 5). Radiographs were taken at regular intervals during the 7-week experimental period. Tissues were embedded in methyl metacrylate (MMA), prepared by the cutting/grinding method, and then stained (Toluidine blue). The discs physiological alterations were qualitatively assessed and classified by inspection of the histological sections. A mean maximum Cobb angle of 30 masculine (+/-6 masculine) and a mean maximum vertebral wedge angle of 10 masculine (+/-3 masculine) were obta...Continue Reading

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Citations

Feb 27, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Carol-Claudius HaslerPhilippe Büchler
Aug 23, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mark DriscollStefan Parent
Mar 19, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bertrand MoalVirginie Lafage
Jul 15, 2011·Medical & Biological Engineering & Computing·Mark DriscollStefan Parent
Jul 28, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anne-Laure MénardIsabelle Villemure
Apr 16, 2013·The Spine Journal : Official Journal of the North American Spine Society·Alex K RothLodewijk W van Rhijn
Jun 7, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anne-Laure MénardIsabelle Villemure
Oct 11, 2015·Biomechanics and Modeling in Mechanobiology·Rosa KavianiIsabelle Villemure
Feb 15, 2011·Clinical Biomechanics·M P ShillingtonC J Adam
May 27, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carlos BarriosViviana Bisbal
Jan 7, 2011·Clinical Orthopaedics and Related Research·Ashish PatelJean Pierre Farcy
Jan 5, 2011·Journal of Pediatric Orthopedics·James Sanders
Mar 25, 2020·Clinical Spine Surgery : a Spine Publication·Sachiko KawasakiYasuhito Tanaka
Jan 14, 2010·Current Opinion in Pediatrics

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