PMID: 8964919May 1, 1996Paper

A novel ganglioside, 9-O-acetyl GD1b, is recognized by serum antibodies in Guillain-Barré syndrome

Journal of Neuroimmunology
S HitoshiI Kanazawa

Abstract

A hitherto undescribed ganglioside was detected in a crude ganglioside fraction of bovine brain using an IgM M-protein binding to Gal beta 1, 3GalNAc residue. We purified and identified it as 9-O-acetyl GD1b based on results of alkali treatment that yielded GD1b and results of fast atom bombardment-mass and gas chromatography-mass spectrometries. 9-O-acetyl GD1b was also found to be present in human peripheral nerve tissue. The reactivities of the serum antibodies from patients with Guillain-Barré syndrome to 9-O-acetyl GD1b, GD1b, and GM1 were determined by ELISA and TLC immunostaining. Nineteen of 85 serum samples from Guillain-Barré syndrome patients had antibodies that bound to 9-O-acetyl GD1b: 14 of the positive samples also reacted with GM1 and GD1b, three reacted with GM1 but not with GD1b, one with GD1b but not with GM1, and one with neither GM1 nor GD1b. These results show that a subset of patients with Guillain-Barré syndrome had antibodies that react with 9-O-acetyl GD1b; therefore, this ganglioside can serve as a target antigen against the antibodies present in Guillain-Barré syndrome.

References

Sep 1, 1991·Neuroscience Research·M Yamamoto, G Schwarting
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Citations

Oct 17, 1998·Clinical Reviews in Allergy & Immunology·J W TerryberryJ B Peter
Jun 26, 2012·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Susumu Ando
Oct 10, 2015·Mediators of Inflammation·Ying WangHong-Liang Zhang
Oct 14, 2016·The Journal of Organic Chemistry·Hai YuXi Chen
Jul 21, 1998·Annals of the New York Academy of Sciences·R K Yu, T Ariga
May 23, 2000·Journal of Neurochemistry·J Abad-RodríguezM Nieto-Sampedro
Jan 7, 2020·Current Medicinal Chemistry·Konstantin Andreev

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