A Novel Grading System Based on Tumor Budding and Cell Nest Size Is a Strong Predictor of Patient Outcome in Esophageal Squamous Cell Carcinoma

The American Journal of Surgical Pathology
Moritz JesinghausWilko Weichert

Abstract

The determination of prognosis in patients with esophageal squamous cell carcinoma (ESCC) is primarily based on staging according to the TNM-classification, whereas conventional grading is of minor clinical importance because of its deficiencies in prognostic patient stratification. Recently, a novel, highly prognostic grading scheme based on budding activity and cell nest size has been proposed for squamous cell carcinoma (SCC) of both pulmonary as well as oral origin. In order to investigate the utility and transferability of this approach to ESCC, we evaluated budding activity and cell nest size, as well as other histomorphologic characteristics, in a cohort of 135 primarily resected tumors and correlated the results with clinicopathologic and outcome parameters. High budding activity and small cell nest size showed a strong association with reduced overall, disease-specific, and disease-free survival (P<0.001, respectively) in ESCC. The combination of both markers in a 3-step grading system showed excellent prognostic separation of well-differentiated (G1), moderately differentiated (G2), and poorly differentiated (G3) carcinomas (P<0.001). The hazard ratio for disease-free survival in multivariate analysis under inclusion ...Continue Reading

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Citations

Feb 7, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kyra B Berg, David F Schaeffer
Dec 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie BoxbergAndreas Kolk
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Oct 2, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Haiyan ShiBingjian Lu

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