A novel grapheme oxide-modified collagen-chitosan bio-film for controlled growth factor release in wound healing applications

Materials Science & Engineering. C, Materials for Biological Applications
Ting LiuXu Peng

Abstract

Collagen-chitosan composite film modified with grapheme oxide (GO) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), termed CC-G-E film, was loaded with basic fibroblast growth factor (bFGF) as the development of an efficacious wound healing device. In this study we report a novel drug delivery system that prevents the initial burst release and loss of bioactivity of drugs in vitro and in vivo applications. The results showed that CC-G-E film possessed improved thermal stability and a higher rate of crosslinking with increased mechanical properties when the dosage of GO was between 0.03% and 0.07%. It was shown that the in vitro release of bFGF from CC-G-E film continued for more than 28d. Furthermore, the CC-G-E films demonstrated excellent in vitro biocompatibility following culture with L929 fibroblasts in terms of cell adhesion and proliferation. CC-G-E films were implanted into Sprague-Dawley rats to characterize their ability to repair full-thickness skin wounds. Results showed that the CC-G-E film accelerated the wound healing process compared with the blank control. Based on all the results, it was concluded that CC-G-E film operates as a novel drug delivery system and due to its performance in woun...Continue Reading

Citations

Mar 19, 2019·Journal of Biomedical Materials Research. Part a·Shankar A GawareSangeeta N Kale
Aug 8, 2020·Frontiers in Cell and Developmental Biology·Ayan NurkeshArman Saparov
Jul 2, 2020·International Journal of Nanomedicine·Yan WangQi Li
Dec 17, 2020·Materials·Ruxandra-Elena Geanaliu-Nicolae, Ecaterina Andronescu
Jul 29, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Parisa HeydariShaghayegh Haghjooy Javanmard
Jul 4, 2018·Chemical Reviews·Toktam NezakatiAlexander M Seifalian
Sep 2, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Wendy ChenQuan-Li Li

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