A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors

Neurogenetics
Kyle R UrquhartL Lu

Abstract

Genetic differences mediate individual differences in susceptibility and responses to stress and ethanol, although, the specific molecular pathways that control these responses are not fully understood. Heat shock protein alpha 8 (Hspa8) is a molecular chaperone and member of the heat shock protein family that plays an integral role in the stress response and that has been implicated as an ethanol-responsive gene. Therefore, we assessed its role in mediating responses to stress and ethanol across varying genetic backgrounds. The hippocampus is an important mediator of these responses, and thus, was examined in the BXD family of mice in this study. We conducted bioinformatic analyses to dissect genetic factors modulating Hspa8 expression, identify downstream targets of Hspa8, and examined its role. Hspa8 is trans-regulated by a gene or genes on chromosome 14 and is part of a molecular network that regulates stress- and ethanol-related behaviors. To determine additional components of this network, we identified direct or indirect targets of Hspa8 and show that these genes, as predicted, participate in processes such as protein folding and organic substance metabolic processes. Two phenotypes that map to the Hspa8 locus are anxiet...Continue Reading

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Citations

Dec 28, 2018·Alcoholism, Clinical and Experimental Research·Emilie T ThébergeKristin M Hamre
Jun 6, 2019·Frontiers in Neuroscience·Elena E TereninaMegan K Mulligan
Dec 20, 2018·Frontiers in Genetics·Diana ZhouLu Lu
Sep 10, 2021·Acta Diabetologica·Marco BuglianiLuciana G Angelini

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