A Novel Hepadnavirus Identified in an Immunocompromised Domestic Cat in Australia

Viruses
Mahdis AghazadehJulia A Beatty

Abstract

High-throughput transcriptome sequencing allows for the unbiased detection of viruses in host tissues. The application of this technique to immunosuppressed animals facilitates the detection of viruses that might otherwise be excluded or contained in immunocompetent individuals. To identify potential viral pathogens infecting domestic cats we performed high-throughput transcriptome sequencing of tissues from cats infected with feline immunodeficiency virus (FIV). A novel member of the Hepadnaviridae, tentatively named domestic cat hepadnavirus, was discovered in a lymphoma sample and its complete 3187 bp genome characterized. Phylogenetic analysis placed the domestic cat hepadnavirus as a divergent member of mammalian orthohepadnaviruses that exhibits no close relationship to any other virus. DNA extracted from whole blood from pet cats was positive for the novel hepadnavirus by PCR in 6 of 60 (10%) FIV-infected cats and 2 of 63 (3.2%) FIV-uninfected cats. The higher prevalence of hepadnavirus viraemia detected in FIV-infected cats mirrors that seen in human immunodeficiency virus-infected humans coinfected with hepatitis B virus. In summary, we report the first hepadnavirus infection in a carnivore and the first in a companion...Continue Reading

References

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Citations

May 30, 2020·Nature Reviews. Gastroenterology & Hepatology·Peter A RevillMargaret Littlejohn
Jul 25, 2019·Scientific Reports·Gianvito LanaveMichele Camero
Sep 12, 2018·Viruses·Mahdis AghazadehJulia A Beatty
Dec 29, 2020·Veterinary World·Zahraa Mustafa Al-JumaaMohammad Osamah Dahl
Feb 2, 2021·Veterinary Microbiology·Paolo CapozzaVito Martella
Jun 3, 2021·Viruses·Julia A Beatty, Katrin Hartmann
Jul 3, 2021·Viruses·Paolo CapozzaVito Martella
Mar 19, 2019·Virology·Fang-Yuan NieYong-Zhen Zhang
Oct 5, 2021·Transboundary and Emerging Diseases·Wendy K JoJan Felix Drexler

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Datasets Mentioned

BETA
SUB3718346
MH307930
KX058433

Methods Mentioned

BETA
PCR

Software Mentioned

Diamond
blastn
PhyML
Geneious
Trinity
TrimAl
MAFFT
Diamond blastx

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