A novel herbal preparation desensitizes mesenteric afferents to bradykinin in the rat small intestine

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
M H MuellerM E Kreis

Abstract

Herbal preparations are evolving as promising agents for the treatment of functional gastrointestinal disorders which are considered to be secondary to visceral hypersensitivity. We aimed to determine whether a new combination of six herbal extracts reduces the sensitivity of intestinal afferents in rat. Male Wistar rats (250-350 g, n = 6 per group) were gavaged with either vehicle or 2.5, 5 or 10 mL kg(-1) of STW 5-II, a herbal preparation which contains six extracts. Two hours later, animals were anaesthetized and extracellular multi-unit mesenteric afferent nerve recordings were obtained in the proximal jejunum in vivo. Afferent discharge to 5-hydroxy-tryptamine (5-HT) (5, 10, 20 and 40 microg kg(-1), i.v.), luminal distension (0-60 mmHg) and bradykinin (BK) (15, 30 and 60 microg kg(-1), i.v.) was recorded. At baseline, spontaneous afferent discharge was not different following pretreatment with the various doses of STW 5-II compared with vehicle. The pressure-dependent increase in afferent discharge to intraluminal ramp distension and the dose-dependent increase in afferent firing following 5-HT were also uninfluenced by STW 5-II pretreatment. In contrast, the afferent nerve responses to 15, 30 and 60 microg kg(-1) of BK we...Continue Reading

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Citations

May 24, 2012·Pain Research and Treatment·Mellar P Davis
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Sep 2, 2009·Biological & Pharmaceutical Bulletin·Jing-Tian XieChun-Su Yuan
Jun 11, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed ElbadawiThomas Efferth

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