A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties

International Journal of Pharmaceutics
Laura Martinez-MarcosGavin W Halbert

Abstract

The main aim of the research focused on the production of hot-melt extrusion (HME) formulations with increased dissolution properties of albendazole (ABZ). Therefore, HME was applied as a continuous manufacturing technique to produce amorphous solid dispersions of the poorly water soluble drug ABZ combined with the polymer matrix polyvinylpyrrolidone PVP K12. HME formulations of ABZ-PVP K12 comprised a drug content of 1%, 5% and 10% w/w. The main analytical characterisation techniques used were scanning electron microscopy (SEM), micro-computed tomography (μ-CT), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution profile studies. The application of SEM, XRPD and DSC evidenced drug physical transformation from crystalline to amorphous state and therefore, the achievement of an amorphous solid dispersion. The introduction of a novel technique, μ-CT, to characterise the internal structure of these materials revealed key information regarding materials distribution and void content. Dissolution profile studies evidenced a high increase in drug release profile compared to pure ABZ. These promising results can lead to a great enhancement of the oral bioavailability of ABZ dosage forms. Therefore,...Continue Reading

References

Jan 1, 1986·European Journal of Clinical Pharmacology·S E MarrinerJ A Bogan
Feb 14, 2004·Advanced Drug Delivery Reviews·Geoff G Z ZhangYihong Qiu
May 8, 2004·International Journal of Pharmaceutics·I C SinkaJ C Cunningham
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marc LindenbergJennifer B Dressman
Jul 10, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S StegemannH Lindén
Sep 25, 2007·Drug Development and Industrial Pharmacy·Michael M CrowleyCharles Martin
Oct 27, 2007·Drug Development and Industrial Pharmacy·Michael A RepkaJames W McGinity
Apr 18, 2009·Journal of Pharmaceutical Sciences·Joachim BrouwersPatrick Augustijns
Jun 25, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E VerhoevenC Vervaet
Dec 2, 2009·Nature Reviews. Drug Discovery·Bernard Munos
Jan 30, 2010·Journal of Pharmaceutical Sciences·Marco B PranzoRuggero Bettini
Aug 24, 2010·International Journal of Pharmaceutics·Sandra U Schilling, James W McGinity
Aug 31, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Barry CreanClive J Roberts
Aug 17, 2011·Advanced Drug Delivery Reviews·Jared A Baird, Lynne S Taylor
Sep 20, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shital M MaruAnant Paradkar
Nov 24, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohammed ManiruzzamanDennis Douroumis
Jan 4, 2012·Journal of Pharmaceutical Sciences·Ann NewmanGeorge Zografi
Dec 25, 2012·International Journal of Pharmaceutics·Mohammed ManiruzzamanDennis Douroumis
Aug 21, 2013·International Journal of Pharmaceutics·Stefano BiancoAnne Marie Healy
Aug 8, 2014·International Journal of Pharmaceutics·Andreas EitzlmayrJohannes Khinast
Dec 30, 2014·International Journal of Pharmaceutics·J ThiryB Evrard
Jul 19, 2015·International Journal of Pharmaceutics·A L KellyA Paradkar
Aug 2, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A-K VynckierC Vervaet

❮ Previous
Next ❯

Citations

Oct 21, 2016·Drug Development and Industrial Pharmacy·Soraya Hengsawas SurasarangRobert O Williams
May 20, 2017·Pharmaceutical Research·Khadijah EduengChristel A S Bergström
Oct 28, 2019·Pharmaceutical Development and Technology·Arabella M McLaughlinXiong-Wei Ni
Aug 11, 2016·Pharmaceutical Research·Tochukwu C OkwuosaMohamed A Alhnan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.