A novel human acute encephalitis caused by pseudorabies virus variant strain.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Qingyun LiuWei Li

Abstract

Pseudorabies virus (PRV) is a common pathogen in multiple animal species particularly in pigs. However, PRV infection in humans is rare and to the best of knowledge, PRV has never been isolated from human cases before. Four acute encephalitis cases in humans were confirmed as PRV infection based on clinical symptoms, laboratory diagnosis, and metagenomic next-generation sequencing (mNGS). Cerebrospinal fluid (CSF) samples were collected and applied for virus isolation. Etiological and genetic characteristics of this PRV human isolate were further determined. The patients manifested respiratory dysfunction and acute neurological symptoms. The mNGS revealed PRV specific nucleotide sequences in patients' CSF samples (7-6198 reads and 0.2446%-80.58% coverage). The PRV envelope glycoprotein B antibody, glycoprotein E antibody, and neutralizing antibody were positively detected. For the first time, a PRV strain, designated hSD-1/2019, was isolated and identified from one CSF sample, and transmission electron microscopy revealed hSD-1/2019 had typical morphology similar to swine PRV. Phylogenetic analysis illustrated that hSD-1/2019 was genetically closest to those PRV variant strains currently circulating in pigs in China, and this s...Continue Reading

References

Mar 1, 1989·Veterinary Microbiology·E MocsáriL Zsák
Feb 28, 1987·Lancet·S MravakK O Habermehl
Oct 1, 1980·Journal of Wildlife Diseases·C M KirkpatrickS M McCrocklin
Sep 20, 2001·Comparative Immunology, Microbiology and Infectious Diseases·G R SkinnerJ A Davies
Nov 16, 2004·Journal of Virology·Elizabeth E BrittleL W Enquist
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Lisa E PomeranzChristoph J Hengartner
Aug 13, 2011·Archives of Virology·T MüllerC Freuling
Oct 25, 2011·Lancet·Burcin EkserDavid K C Cooper
Nov 6, 2013·Emerging Infectious Diseases·Tong-Qing AnGuang-Zhi Tong
Oct 29, 2015·Veterinary Microbiology·Wu TongGuang-zhi Tong
Jan 23, 2016·Veterinary Microbiology·Yuan SunHua-Ji Qiu
Feb 13, 2016·World Journal of Virology·Qing-Yuan YangKe-Gong Tian
May 19, 2018·Emerging Infectious Diseases·Jing-Wen AiWen-Hong Zhang
Dec 28, 2018·The Journal of Infectious Diseases·Wanting HeShuo Su
Jun 20, 2019·Frontiers in Neurology·HongNa YangShiFang Ding
Jul 22, 2019·Transboundary and Emerging Diseases·Liheng ZhengErhei Dai
Aug 14, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Xue YangYiming Liu
Sep 29, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yuwei WangYan Cui
Jan 4, 2020·Journal of Neurovirology·Di WangJinquan Wang

❮ Previous
Next ❯

Citations

Aug 14, 2020·Transboundary and Emerging Diseases·Jinbiao LiuXiangdong Li
Oct 7, 2020·Animals : an Open Access Journal From MDPI·Fengsun WuWengang Li
Sep 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Qingyun LiuXiangru Wang
Feb 7, 2021·International Journal of Biological Macromolecules·Teng ZhangGaiping Zhang
Nov 21, 2020·Pathogens·Flavia Pruiti CiarelloVincenzo Di Marco Lo Presti
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Hongchao GouChunling Li
Feb 23, 2021·Virologica Sinica·Lei TanAibing Wang
Mar 29, 2021·Journal of Veterinary Science·Chun Zhi RenTing Jun Hu
Apr 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hui-Hua ZhengHong-Ying Chen
Dec 3, 2020·Seminars in Immunology·Lilit Grigoryan, Bali Pulendran
Jun 22, 2021·Frontiers in Microbiology·Hongchao GouChunling Li
Jul 20, 2021·BMC Veterinary Research·Lixia LiXu Song
Aug 3, 2021·International Journal of Biological Macromolecules·Teng ZhangGaiping Zhang
Sep 27, 2020·BMC Veterinary Research·Lang GongGuihong Zhang
Oct 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yiyi ZhouDaojun Hong

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.