PMID: 3501781Nov 1, 1987Paper

A novel human class II specificity, DQ "Wa," resides on DQ molecules of DR4,Dw15 and DRw8,Dw8 B-cell lines identified as DQ "blank"

Human Immunology
T EndoN Kashiwagi

Abstract

The molecular localization of a novel human class II specificity, DQ "Wa," was investigated. A monoclonal antibody, HU46, which has previously been shown to react with DR4, Dw15 and DRw8, Dw8 B cells that type as DQ "blank," was used for the isolation and structural characterization of class II molecules bearing the DQ "Wa" determinant. The partial N-terminal sequence analysis of class II molecules bearing the DQ "Wa" determinant, purified from two B-cell lines, EBV-Wa (DR4, Dw15, DQ "blank") and GI (DRw8, Dw8, DQ "blank"), shows that the alpha and beta chain sequences are homologous to HLA-DQ. Within the limits of our analysis, the alpha and beta chains from both cell lines are identical. Both beta chains possess a phenylalanine residue at position 9 that differs from the tyrosine residue present at this position in beta chains of DQ alleles. These studies indicate that a novel human class II specificity, DQ "Wa," resides on a new allelic form of DQ molecules found in DR4, Dw15 and DRw8, Dw8 cells that are DQ "blank."

References

Oct 30, 1976·Lancet·A WakisakaE Nakayama
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K GregersenJ Schwenzer
Nov 1, 1982·The Journal of Experimental Medicine·C K HurleyJ D Capra
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C O BenoistH O McDevitt
Jan 1, 1984·American Journal of Nephrology·Y NomotoK Tsuji
Jan 1, 1982·Immunological Reviews·D A ShackelfordJ L Strominger
Aug 1, 1983·Immunology Today·C Katovich HurleyJ Donald Capra
Mar 1, 1985·Immunology Today·F H Bach

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