A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9

Genomics
Y H EdwardsJ H Ives

Abstract

The phosphoglucomutases (PGM1-3) in humans are encoded by three genes, PGM1, PGM2, and PGM3. These enzymes are central to carbohydrate metabolism. All three isozymes show genetic variation, and PGM1 has achieved prominence as a key marker in genetic linkage mapping and in forensic science. The human PGM genes are assumed to have arisen by gene duplication since their products are broadly similar in structure and function; however, direct proof of their evolutionary relationship is not available because only PGM1 has been cloned. During a search for other members of the PGM family, a novel sequence with homology to PGM1 was identified. Mapping using fluorescence in situ hybridization and somatic cell hybrids locates this gene to the centromeric region of chromosome 9. RT-PCR and Northern analysis indicate that this is an expressed PGM gene with widespread distribution in adult and fetal tissues. We propose that this gene be designated PGM5 and that it represents a novel member of the PGM family.

Citations

May 31, 2001·Genome Research·E MakrinouY H Edwards
Jul 14, 2010·Arquivos brasileiros de endocrinologia e metabologia·Karina Kores DorsaMagnus R Dias da Silva
Jan 21, 2017·Scientific Reports·Prashantha HebbarOsama Alsmadi
Feb 24, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·E Wyroba, B H Satir
Oct 5, 2019·Cancer Cell International·Yifan SunYongqi Shen
Apr 8, 2017·Scientific Reports·A M OlivaresN B Haider
Jan 16, 2019·Nature Genetics·Vinayak BhandariRobert G Bristow

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