A novel human rotavirus serotype with dual G5-G11 specificity

The Journal of General Virology
M do C TimenetskyYasutaka Hoshino

Abstract

Rotavirus serotype G5 isolates were recently recovered from children with diarrhoea in Brazil. Like most human strains, they exhibited long electropherotypes and subgroup II and Wa-like VP4 specificity. We report the successful propagation and the molecular and antigenic characterization of one of these isolates (IAL-28). Cross-neutralization of IAL-28 and a single gene reassortant, UK x IAL-28, which contains the gene encoding the IAL-28 VP7 in the UK genomic background, with prototype G1 to G14 rotaviruses demonstrated that IAL-28 has antigenic determinants specific for both G5 and G11 serotypes. Sequence analysis of the gene encoding VP7 suggested that one or two amino acid substitutions at positions 96 and 100 on IAL-28 VP7 were possibly responsible for the additional G11 specificity. G5 rotaviruses are found in horses and predominate in piglets, whereas G11 has been identified exclusively as a swine pathogen.

Citations

Jul 20, 2004·Journal of Medical Virology·Rita Cássia Compagnoli CarmonaCelso Francisco Hernandes Granato
Aug 14, 2012·Veterinary Microbiology·Wilaiporn SaikruangNiwat Maneekarn
Jun 24, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ricardo Q GurgelLuis E Cuevas
Sep 25, 2008·Journal of Medical Virology·Hamsa T TayebMichael J Carter
Aug 16, 2014·Veterinary Microbiology·Rebecca Chandler-BostockKenneth M Mellits
May 17, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Adriana LuchsMaria do Carmo Sampaio Tavares Timenetsky
Dec 7, 2010·Veterinary Microbiology·M MoniniF M Ruggeri
Apr 3, 2010·Veterinary Microbiology·Hyun-Jeong KimSu-Jin Park
Oct 9, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C J Téllez CastilloJ Buesa Gómez
Dec 17, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·P A BarrilS V Nates
May 23, 1998·Journal of Medical Virology·H WuS Urasawa
Jun 7, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Adriana LuchsMaria do Carmo Sampaio Tavares Timenetsky
Mar 22, 2007·Journal of Medical Microbiology·Joana D'Arc P MascarenhasAlexandre C Linhares
May 19, 2006·Emerging Infectious Diseases·Rita Cássia Compagnoli CarmonaLeonardo José Richtzenhain
Oct 18, 2000·Cadernos de saúde pública·A C Linhares
Aug 5, 2010·Ciência & saúde coletiva·Telma Maria Evangelista de AraújoMaria Amélia de Oliveira Costa
Dec 9, 1998·Molecular and Cellular Probes·N SantosV Gouvea
Oct 17, 1998·Journal of Clinical Microbiology·M RamachandranR I Glass
Nov 8, 2003·Journal of Clinical Microbiology·Sujata S Ranshing, Shobhana D Kelkar
Oct 4, 2000·Journal of Clinical Microbiology·A Rodríguez CastilloH García Lozano
Aug 1, 2002·Journal of Clinical Microbiology·Maria Luzia Rosa E SilvaVera Gouvea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.