A novel hydroxamic acid-containing antibiotic produced by a Saharan soil-living Streptomyces strain

Letters in Applied Microbiology
Amine YekkourNasserdine Sabaou

Abstract

During screening for potentially antimicrobial actinobacteria, a highly antagonistic strain, designated WAB9, was isolated from a Saharan soil of Algeria. A polyphasic approach characterized the strain taxonomically as a member of the genus Streptomyces. The strain WAB9 exhibited a broad spectrum of antimicrobial activity toward various multidrug-resistant micro-organisms. A PCR-based assay of genomic potential for producing bioactive metabolites revealed the presence of PKS-II gene. After 6 days of strain fermentation, one bioactive compound was extracted from the remaining aqueous phase and then purified by HPLC. The chemical structure of the compound was determined by spectroscopic (UV-visible, and (1)H and (13)C NMR) and spectrometric analysis. The compound was identified to be 2-amino-N-(2-amino-3-phenylpropanoyl)-N-hydroxy-3-phenylpropanamide, a novel hydroxamic acid-containing molecule. The pure molecule showed appreciable minimum inhibitory concentration values against a selection of drug-resistant bacteria, filamentous fungi and yeasts. Significance and impact of the study: This study presents the isolation of a Streptomyces strain, named WAB9, from a Saharan soil in Algeria. This strain was found to produce a new hydr...Continue Reading

References

Aug 1, 1994·The Journal of Applied Bacteriology·J M Young, C M Triggs
Aug 18, 1962·Nature·J J GORDONG A MILLER
Nov 19, 2003·Journal of Pharmaceutical and Biomedical Analysis·Harsha Vanjari, Rama Pande
Aug 7, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Massimo Franchini, Dino Veneri
Apr 9, 2005·The Journal of Antibiotics·János Bérdy
Apr 20, 2006·International Journal of Antimicrobial Agents·Abdelaziz TouatiChristophe de Champs
Apr 17, 2009·Current Opinion in Chemical Biology·Sarah M Barry, Gregory L Challis
Nov 15, 2011·Antonie van Leeuwenhoek·Rakesh SanthanamMichael Goodfellow
Jan 1, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hossein JahangirianYadollah Gharayebi

❮ Previous
Next ❯

Citations

Jul 30, 2019·International Journal of Microbiology·Periyasamy SivalingamKandasamy Prabakar
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Samira TataNasserdine Sabaou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.