A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations

International Journal of Pharmaceutics
Jian X WuJukka Rantanen

Abstract

This study focuses on the development of an automated image analysis method to extract information on nucleation and crystal growth from polarized light micrographs. Using the developed image analysis method, four parameters related to nucleation and crystal growth could be extracted from the images. These parameters were crystalline count (applied as a measure of nucleation), percentage area coverage, average equivalent diameter and average crystalline area (three last parameters applied as a measure for crystal growth). The developed image analysis method was used to investigate two pharmaceutically relevant case studies: first, nitrendipine antisolvent crystallization, and second, recrystallization of amorphous piroxicam solid dispersion in an aqueous environment. In both case studies, an amorphous-to-crystalline phase transformation were observed, which were successfully monitored using real-time Raman spectroscopy. For the both case studies, the parameters related to crystallization kinetics estimated by image analysis were in close agreement with the parameters estimated by Raman spectroscopy. The developed image analysis method proved to be a valuable tool for quantitative monitoring of nucleation and crystal growth with...Continue Reading

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Oct 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jian X WuJukka Rantanen

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Citations

Nov 22, 2013·Journal of Pharmaceutical Sciences·Hjalte TrnkaJukka Rantanen
Dec 6, 2012·Journal of Pharmaceutical Sciences·Jian X WuJukka Rantanen
Jan 8, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Krisztina NikowitzGéza Regdon
Apr 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dengning XiaMingshi Yang
Dec 3, 2014·International Journal of Pharmaceutics·Jian X WuJukka Rantanen

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