A novel in vivo model for evaluating agents that protect against ultraviolet A-induced photoaging

The Journal of Investigative Dermatology
T TakeuchiE F Bernstein

Abstract

Increasing evidence demonstrates that ultraviolet A radiation (UVA) contributes to photoaging, which results in the accumulation of massive amounts of abnormal elastic material in the dermis of photoaged skin. To study UVA-induced photoaging in an in vivo system, we utilized a line of transgenic mice containing the human elastin promoter linked to a chloramphenicol acetyl transferase reporter gene. Our prior work demonstrates promoter activation in response to ultraviolet B radiation (UVB), UVA, and psoralen plus ultraviolet A radiation in the skin of these mice. The addition of psoralen (8-MOP) prior to administration of UVA results in substantial increases in promoter activation, as compared with UVA alone. To demonstrate the utility of these mice as a model of UVA-induced photodamage, we administered four lotions to the skin of our transgenic mice that included: a sunscreen containing octyl methoxycinnamate and benzophenone-3 with a sun protection factor (SPF) of 15, the UVA filter butyl methoxydibenzoylmethane, the SPF 15 sunscreen and the UVA filter together, and the lotion vehicle alone. Following sunscreen administration, mice received a single psoralen plus ultraviolet A radiation treatment. All sunscreens decreased chl...Continue Reading

References

Oct 1, 1978·The British Journal of Dermatology·J Barth
Feb 1, 1992·Journal of the American Academy of Dermatology·C Cole, R VanFossen
Jul 1, 1992·Journal of the American Academy of Dermatology·P P Agin, J W Stanfield
Feb 1, 1992·The Journal of Investigative Dermatology·M Garmyn, R Roelandts
Nov 1, 1991·Journal of the American Academy of Dermatology·R WarrenG M Ridder
Aug 1, 1991·Journal of the American Academy of Dermatology·K H Kaidbey, A Barnes
Jan 1, 1990·Journal of the American Academy of Dermatology·C R TaylorB A Gilchrest
Sep 1, 1989·Journal of the American Academy of Dermatology·B A Gilchrest
May 1, 1989·Journal of the American Academy of Dermatology·J W StanfieldL Krochmal
Jul 1, 1989·Journal of the American Academy of Dermatology·R RoelandtsM Garmyn
Nov 1, 1989·Journal of the American Academy of Dermatology·W MontagnaK Carlisle
Mar 1, 1986·Photochemistry and Photobiology·C A ColeR E Davies
Feb 1, 1987·Journal of the American Academy of Dermatology·K Kaidbey, R W Gange
Apr 1, 1985·The Journal of Investigative Dermatology·L H KligmanA M Kligman
Dec 29, 1969·JAMA : the Journal of the American Medical Association·A M Kligman
Mar 1, 1967·The Journal of Investigative Dermatology·R E Mitchell
Jun 1, 1984·The Journal of Investigative Dermatology·K J JohnstonJ Uitto
Apr 1, 1984·International Journal of Dermatology·C Frances, L Robert
Sep 1, 1983·Journal of the American Academy of Dermatology·M JarrattK Smiles
Dec 1, 1983·The Journal of Investigative Dermatology·B StabergH Brodthagen
Jul 1, 1982·The British Journal of Dermatology·D J CrippsA B Lerner
Aug 1, 1982·Photochemistry and Photobiology·J A ParrishR R Anderson
Dec 1, 1995·The Journal of Investigative Dermatology·N J LoweI R Scott
Jan 1, 1995·Journal of the American Academy of Dermatology·R M LavkerK H Kaidbey
Aug 1, 1994·The Journal of Investigative Dermatology·E F BernsteinJ Uitto
May 1, 1994·Journal of the American Academy of Dermatology·C Cole
Jan 1, 1997·The Journal of Investigative Dermatology·R Lavker, K Kaidbey

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Citations

Feb 28, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Eric F Bernstein
Jun 10, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J K Rivers
Aug 30, 2011·Maturitas·Deanne Mraz Robinson, Sumaira Z Aasi
Mar 15, 2006·International Journal of Dermatology·Shringi Sharma, Indu Pal Kaur
Jun 20, 2006·Journal of the American Academy of Dermatology·Jessica H RabeDaniel N Sauder
Jan 8, 2000·Dermatologic Clinics·N Lawrence

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