A novel inhibitor of bacterial endotoxin derived from cinnamon bark

Biochemical and Biophysical Research Communications
S AzumiK Tanamoto

Abstract

A substance that inhibits the activity of bacterial endotoxin (LPS) was found in cinnamon bark. The inhibitor, extracted from dry cinnamon bark with 67% ethanol/water, was purified by using Limulus gelation activity as an indicator of endotoxin activity. The inhibitor suppressed the activity of the LPS when it was mixed with the inhibitor prior to the assay. The reduction of the LPS activity depended on the concentration of both the inhibitor and LPS when mixed, and also on the incubation time. The inhibitor suppressed the activity of all LPS and lipid A preparations tested regardless of the origin of the bacteria. The inhibitor alone did not affect the Limulus system. These results indicate that the inhibition was caused by direct interaction of the inhibitor with the LPS molecule. Furthermore the inhibitor abrogated the pyrogenicity of the LPS. Although it is uncertain whether the inhibitor actually plays a role in the defense mechanism in cinnamon bark, this is the first report that an inhibitor of bacterial endotoxin exists in a plant.

Citations

Oct 24, 2000·Proceedings of the Society for Experimental Biology and Medicine·N M FilipovC K Smith
May 2, 2003·The British Journal of Nutrition·Nicole GottsteinGerald Rimbach
Oct 7, 2010·Critical Reviews in Food Science and Nutrition·Joerg GruenwaldNicole Armbruester
Feb 28, 2007·Journal of Ethnobiology and Ethnomedicine·Cheryl LansWilli Boepple
May 11, 2004·Biological & Pharmaceutical Bulletin·Kiichiro KawaguchiYoshio Kumazawa
Feb 24, 2001·Drug Metabolism and Drug Interactions·H MoiniL Packer
May 1, 2008·Indian Journal of Pediatrics·Luca RostiAlessandra Frigiola
Sep 30, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G RimbachP D Weinberg
Sep 24, 2009·Molecular Nutrition & Food Research·Alicja MortensenGerhard Sontag
Nov 13, 2007·Journal of Gastroenterology and Hepatology·Rupjyoti Talukdar, Rakesh K Tandon
Jul 19, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rupjyoti TalukdarRakesh Tandon
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Christopher A VarnonCharles I Abramson
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bharath Kumar VelmuruganChing-Feng Weng
Nov 16, 2004·Journal of Animal Science·E G ManzanillaJ Gasa
Jan 8, 2009·The Journal of Nutrition·Giridhar KanuriIna Bergheim
Mar 7, 2002·Journal of Agricultural and Food Chemistry·Shang-Tzen Chang, Sen-Sung Cheng
May 27, 2004·Journal of Agricultural and Food Chemistry·María García-AlonsoSonia De Pascual-Teresa
Oct 4, 2005·Pediatrics·Luca Rosti, Gilda Gastaldi

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