A novel intranasal mouse model for mucosal colonization by Streptococcus suis serotype 2

Journal of Medical Microbiology
Maren SeitzChristoph Georg Baums

Abstract

Streptococcus suis causes meningitis and various other diseases in pigs and humans. Healthy piglets carrying virulent Streptococcus suis strains on their mucosal surfaces are epidemiologically very important. The objective of this study was to establish an intranasal Streptococcus suis mouse model for invasion and colonization of the respiratory tract. CD1 mice were infected intranasally with a highly virulent Streptococcus suis serotype 2 strain under different conditions. Clinical, histological and bacteriological screenings revealed that invasion of host tissue occurred in the majority of mice only after predisposition with 12.5 µl 1 % acetic acid per nostril. Severe fibrinosuppurative or purulent necrotizing pneumonia associated with Streptococcus suis was a common manifestation. Furthermore, a novel model to study nasopharyngeal colonization was established by reducing the volume of 1 % acetic acid per nostril to 5 µl prior to Streptococcus suis application. This model mimics asymptomatic carriage in swine, as all mice carried Streptococcus suis on their respiratory mucosa at 7 days post-infection (p.i.) in moderate to high numbers without the development of pneumonia or any other invasive Streptococcus suis disease. This ...Continue Reading

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Citations

Jul 1, 2016·Future Microbiology·Tobias TenenbaumChristian Schwerk
Jan 4, 2017·PloS One·Daniel B GilmerVincent A Fischetti
Jan 10, 2018·Frontiers in Microbiology·Nikolai SiemensSven Hammerschmidt
Jul 5, 2018·BMC Infectious Diseases·Jana SeeleRoland Nau
Sep 14, 2018·The Journal of Veterinary Medical Science·Tetsuya KomatsuTomoyuki Shibahara
Oct 31, 2018·Veterinary Research·Audrey DumesnilMarcelo Gottschalk

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