A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE

Biochemical and Biophysical Research Communications
Zhengfang YiXiushan Wu

Abstract

The zinc-finger motif found in many transcription factors is thought to be important for human heart development and diseases. In this study, we have identified and characterized a novel zinc-finger gene named ZNF480 using degenerate primers from an early human embryo heart cDNA library. ZNF480 contains a KRAB-A box and 12 C2H2 zinc fingers. The cDNA sequence contains an open reading frame of 1551 bp, encoding a putative protein of 516 amino acid residues with a predicted molecular mass of 57 kDa. Northern blot analysis indicates that a 4.7kb transcript specific for ZNF480 is expressed only in embryonic heart. In the adult tissues, the expression of ZNF480 is restricted largely to heart, skeletal muscle, pancreas, and placenta. Overexpression of ZNF480 in cells activates the transcriptional activities of AP-1 and SRE. Therefore, our data suggest that ZNF480 may act as a positive regulator in MAPK-mediated signaling pathways that lead to the activation of AP-1 and SRE.

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Citations

May 25, 2007·FEBS Letters·Matthew Robert MysliwiecYoungsook Lee
Aug 22, 2009·Biochemical and Biophysical Research Communications·Yasuhide ItokawaTakahiro Nagase
Aug 30, 2008·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Aidong ZhouJian Zhang
Jul 1, 2008·Biology of the Cell·Juan Carlos PolancoPeter Koopman
Jun 7, 2005·Biochemical and Biophysical Research Communications·Fang LiuMingyao Liu
Jul 4, 2006·Biochemical and Biophysical Research Communications·Zhiming XiangYongqing Li
Dec 14, 2005·Biochemical and Biophysical Research Communications·Xingzhu QiXiushan Wu
Feb 9, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Zhengfang YiZirong Wu
Nov 28, 2018·International Journal of Environmental Research and Public Health·Dang Ton NguyenVan Hai Nong
Dec 18, 2007·Molecular and Cellular Biochemistry·Yongqing LiXiushan Wu

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