A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation.

The Journal of Biological Chemistry
N Toyama-SorimachiM Miyasaka

Abstract

The lymphocyte adhesion molecule CD44 recognizes a non-hyaluronate proteoglycan, gp600, secreted by mouse T cell line CTLL2. We now demonstrate that gp600 is identical to serglycin, a member of the small proteoglycan family stored in intracellular secretory granules of lymphoid, myeloid, and some tumor cells. Purified gp600 has the ability to bind specifically to CD44, and the binding is dependent on activation of CD44. The CD44-binding elements on gp600 or serglycin are glycosaminoglycans consisting of chondroitin 4-sulfate. Serglycin is readily exocytosed, and its interaction with active form CD44 augments the CD3-dependent degranulation of CD44 positive CTL clones. We conclude that the serglycin secreted from secretory granules of hematopoietic cells is a novel ligand for CD44, and could regulate lymphoid cell adherence and activation.

References

Feb 1, 1992·The Journal of Cell Biology·S Jalkanen, M Jalkanen
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A SethP S Nagarkatti
Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Jul 14, 1989·Biochemical and Biophysical Research Communications·K SugaharaI Yamashina
Dec 1, 1989·Immunology Today·B F HaynesS M Denning
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S AvrahamJ H Weis
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R V TantravahiJ H Weis
Mar 1, 1986·Cellular Immunology·D Levitt, L Olmstead
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J MillerS E Cullen
Dec 1, 1985·The Journal of Experimental Medicine·A J SantB D Schwartz
Apr 1, 1985·Nature·M S Pasternack, H N Eisen
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A BourdonE Ruoslahti
Apr 1, 1994·International Immunology·N Toyama-Sorimachi, M Miyasaka
Aug 1, 1993·Immunology Today·P HerrlichH Ponta
Jan 1, 1993·Advances in Immunology·J LesleyP W Kincade
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

❮ Previous
Next ❯

Citations

Jun 15, 1996·Journal of Cellular Biochemistry·J EntwistleE A Turley
Jun 1, 1997·Journal of Cellular Physiology·M RöselM Zöller
Oct 10, 1998·Journal of Cellular Physiology·M A BurgW B Stallcup
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Nakamura, H Ozawa
May 9, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K J NoonanJ W Stevens
Oct 9, 2002·Medicinal Research Reviews·Koichi Honke, Naoyuki Taniguchi
Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J M SorreliA I Caplan
May 13, 1999·Progress in Histochemistry and Cytochemistry·K Ostergaard, D M Salter
Jun 23, 1999·Experimental Hematology·S GhaffariC Eaves
Apr 1, 2000·Biochimica Et Biophysica Acta·O Habuchi
Dec 22, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M H Kuehn, G S Hageman
Sep 23, 2003·Current Opinion in Immunology·Srikumar M RajaChristopher J Froelich
Oct 23, 1997·Current Opinion in Cell Biology·P W KincadeL Hanson
Apr 25, 2003·Critical Reviews in Oncology/hematology·Tracey A MartinWen G Jiang
Aug 1, 2007·Animal : an International Journal of Animal Bioscience·X YangR Zhao
Jul 1, 1995·Nature Medicine·D L Cooper, G J Dougherty
Jun 10, 2005·The New England Journal of Medicine·Mayana Zatz, Alessandra Starling
Sep 1, 1996·The Journal of Experimental Medicine·Y GuoY Liu
Aug 20, 2002·Journal of Hematotherapy & Stem Cell Research·Andrés HidalgoJoaquin Teixidó
Dec 10, 2002·Hybridoma and Hybridomics·S M DavernS J Kennel
Jun 25, 1998·Glycobiology·M A KulsethS O Kolset
Oct 2, 1998·Tissue Antigens·M RöselM Zöller
Dec 1, 1996·The Australian and New Zealand Journal of Surgery·M V Agrez
Aug 19, 2005·Molecular and Cellular Biology·Catherina H BirdPhillip I Bird
Jun 1, 1996·Clinical Molecular Pathology·S O SuzukiJ Tateishi
Apr 1, 1997·Molecular Pathology : MP·Z Rudzki, S Jothy
Mar 1, 2000·Molecular Pathology : MP·S GoodisonD Tarin
Apr 14, 2011·American Journal of Physiology. Endocrinology and Metabolism·Young S LeeKeith E Latham
Sep 3, 1998·The Journal of Clinical Investigation·J MollP Herrlich
Dec 5, 2006·Biological & Pharmaceutical Bulletin·Hiroto Kawashima
Nov 10, 2013·PloS One·Angeliki KorpetinouAchilleas D Theocharis
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·L RobinsonA Seth
Sep 2, 2011·Chinese Journal of Cancer·Xin-Jian Li, Chao-Nan Qian
Feb 27, 1999·Leukemia & Lymphoma·L J Bendall, D J Gottlieb
May 26, 1999·Leukemia & Lymphoma·R RistamäkiS Jalkanen
May 1, 1996·Leukemia & Lymphoma·F Smadja-JoffeJ P Levesque

❮ Previous
Next ❯

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