A novel liposome-encapsulated hemoglobin/silica nanoparticle as an oxygen carrier

International Journal of Pharmaceutics
Mingxian LiuLongwu Chen

Abstract

A novel liposome-encapsulated hemoglobin/silica nanoparticle (LEHSN) was fabricated by a water-in-oil-in-water (W/O/W) double emulsion approach. Bovine hemoglobin (Hb) was first adsorbed onto the surfaces of silica nanoparticles (SNs), and then the complex of Hb/SNs was encapsulated by liposome to form LEHSN which has a core-shell supramolecular structure. On the one hand, liposomes built a cell membrane-like environment for the controlled release of Hb. On the other hand, SNs which act as rigid core provide a supported framework for lecithin membrane, and enhance the stability of liposomes. In comparison with liposome-encapsulated Hb (LEH), LEHSN shows substantially enhanced stability and improved release property of Hb in vitro. This study highlights the potential of the novel LEHSN as an oxygen carrier for pharmaceutical applications.

References

Sep 15, 2004·International Journal of Pharmaceutics·V D AwasthiB A Goins
Dec 29, 2004·Biomaterials·Shuliang LiAndre Francis Palmer
Nov 10, 2009·Colloids and Surfaces. B, Biointerfaces·Hrushikesh AgasheVibhudutta Awasthi

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Citations

Jul 23, 2013·International Journal of Pharmaceutics·Alexandru Mihai GrumezescuMariana Carmen Chifiriuc
Nov 26, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Wenquan ZhuSiling Wang
Nov 20, 2016·International Journal of Pharmaceutics·Zahraa Al-AhmadyKostas Kostarelos
Sep 4, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Zahraa S Al-AhmadyKostas Kostarelos
Feb 20, 2017·Advanced Drug Delivery Reviews·Huaifa Zhang, Jake E Barralet

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