A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green

Scientific Reports
Yoshinori InagakiKiyoshi Hasegawa

Abstract

Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to normal cells and it had superior anti-tumor action compared to gemcitabine alone in a subcutaneous tumor xenograft. ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC.

References

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Nov 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tatehiro KagawaTetsuya Mine

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Methods Mentioned

BETA
fluorescence imaging
xenograft

Software Mentioned

SPSS

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