A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA

Cancer Letters
Jia HeHui Wang

Abstract

Long noncoding RNAs (lncRNAs) are implicated as novel drivers in hepatocellular carcinoma (HCC), but the underlying mechanisms of this relationship with hepatocarcinogenesis are unknown. We report a novel, liver-specific lncRNA LINC01093 that shows significant downregulation in HCC tissues. LINC01093 expression is inversely correlated with cancer embolus and HCC TNM stage and as a prognostic predictor for HCC patients. LINC01093 overexpression significantly suppresses HCC cell proliferation and metastasis in vitro and in vivo. Conversely, its knockdown promotes HCC progression. Mechanistic analyses indicate that LINC01093 directly binds insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), interfering with interaction between IGF2BP1 and glioma-associated oncogene homolog 1 (GLI1) mRNA. The result is degradation of GLI1 mRNA, further affecting expression of GLI1 downstream molecules involved in HCC progression. The liver-enriched lncRNA LINC01093 is a promising prognostic indicator for HCC patients, and the newly identified LINC01093-IGF2BP1-GLI1 axis shows potential for therapeutic targets in HCC.

Citations

Sep 8, 2020·Doklady. Biochemistry and Biophysics·O Y BureninaO A Dontsova
Apr 11, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhonghou RongWenmao Geng
Sep 13, 2020·Journal of Cancer Research and Clinical Oncology·Olga Y BureninaOlga A Dontsova
Sep 3, 2020·Non-coding RNA·Shizuka Uchida, Sakari Kauppinen
Nov 2, 2020·Cancer Letters·Chen XieJin-E Yang
Jan 11, 2021·Journal of Experimental & Clinical Cancer Research : CR·Jun-Jie HuMing-Yi Xu
Feb 2, 2021·Frontiers in Oncology·Yuming XuZhengjun Shang
Apr 25, 2020·Journal of Hepatology·Zhicong ZhaoQiang Xia
Mar 7, 2021·International Journal of Molecular Sciences·Mai-Huong Thi NgoYen-Hua Huang
Apr 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ganglei LiJian Shen
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Enakshi SivasudhanRong Rong
Jul 13, 2021·Investigational New Drugs·Qiu-Ying DuDong-Sheng Pei
Aug 16, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ganesh Kumar BarikBhargab Kalita

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