A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer

Oncogene
Po-Shun WangPei-Jung Lu

Abstract

Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo. Furthermore, we found linc-ZNF469-3 physically interacted with miR-574-5p and overexpression of miR-574-5p attenuated ZEB1 expression. Importantly, endogenous high expressions of linc-ZNF469-3 and ZEB1 were correlated with tumor recurrence in TNBC patients with lung metastasis. Taken together, our findings suggested that linc-ZNF469-3 promotes lung metastasis of TNBC through miR-574-5p-ZEB1 signaling axis and may be used as potential prognostic marker for TNBC patients.

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Citations

Dec 13, 2019·Cancer Science·Qianqian ZhengChenghai Zhao
Sep 8, 2020·Journal of Zhejiang University. Science. B·Juan XuXian-Feng Ding
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Nov 25, 2020·Clinical & Experimental Metastasis·Xiao-Rong YangQing Zhou
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Jun 18, 2021·Frontiers in Oncology·Margherita PiccolellaElio Messi
Jul 28, 2021·Digestive Diseases and Sciences·Jindun Pan, Yunhong Zang

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Methods Mentioned

BETA
RNA-Seq
PCR
xenografts
immunoprecipitation
pull-down
transfection
xenograft
fluorescence-activated cell sorting
FCS
electrophoresis

Software Mentioned

Partek Genomic Suite
Prism5
AMBER
RNAHybrid
SPSS Statistics
ImageJ
Cufflinks
Bowtie2
miRWalk
TopHat

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