A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer

Cell Death & Disease
Yiran LiangQ Yang

Abstract

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in cancerous processes as either oncogenes or tumor suppressor genes. Here, we demonstrated that lncRNA-PRLB (progression-associated lncRNA in breast cancer) was upregulated in human breast cancer tissues and breast cancer cell lines. Further evaluation verified that lncRNA-PRLB was positively correlated with the extent of metastasis, and its expression was correlated with shorter survival time of breast cancer patients. We identified microRNA miR-4766-5p as an inhibitory target of lncRNA-PRLB. Both lncRNA-PRLB overexpression and miR-4766-5p knockdown could remarkably enhance cell growth, metastasis, and chemoresistance. We also determined that sirtuin 1 (SIRT1) was an inhibitory target of miR-4766-5p, and that SIRT1 was inhibited by both lncRNA-PRLB knockdown and miR-4766-5p overexpression. Significantly, we found that the promotion of cell proliferation and metastasis, the acquisition of chemoresistance, and the increased expression of SIRT1 induced by lncRNA-PRLB overexpression could be partly abrogated by ectopic expression of miR-4766-5p. Taken together, our findings indicated that lncRNA could regulate the progression and chemoresista...Continue Reading

References

Apr 17, 2007·Cell Biology International·Chang-Su Lim
May 10, 2011·Trends in Cell Biology·Orly Wapinski, Howard Y Chang
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Jul 31, 2012·PLoS Genetics·Claudia KutterAna C Marques
Aug 2, 2012·Nature Reviews. Clinical Oncology·M Teresa Villanueva
Sep 8, 2012·Genome Research·Balázs BánfaiLeonard Lipovich
Oct 31, 2012·Frontiers in Genetics·Keiko Tano, Nobuyoshi Akimitsu
Nov 28, 2012·Journal of Molecular Biology·Je-Hyun YoonMyriam Gorospe
Apr 23, 2013·Oncogene·M Roth, W Y Chen
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Aug 13, 2013·Cell Death and Differentiation·Z ZhangY-Y Mo
Aug 22, 2014·Molecular Cancer Research : MCR·Lijia ZhuYan Dai
Nov 22, 2014·Nature Communications·Dimple ChakravartyMark A Rubin
Dec 29, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shun FangLinlang Guo
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianguang JinYanhui Yang
May 11, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Peng GuTianxin Lin
Aug 7, 2017·Experimental and Therapeutic Medicine·Quanqing ZouDong Huang

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Citations

Apr 16, 2019·Technology in Cancer Research & Treatment·Tianzhu ZhangZhongxin Lu
Aug 9, 2020·OncoTargets and Therapy·Tonghua DuBin Liu
Mar 20, 2020·Molecular Cancer·Francesca CrudeleStefano Volinia
Oct 24, 2018·Frontiers in Neuroscience·Ying ZhangFeng-Xu Yu
Jan 7, 2020·Cell Biology and Toxicology·Wei ZhanRui Li
Oct 16, 2018·Frontiers in Endocrinology·Sergio LiarteFrancisco José Nicolás
May 10, 2020·Molecular Cancer·Yiran LiangQifeng Yang
Mar 16, 2019·Current Opinion in Chemical Biology·Tatsiana KosciukHening Lin

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Methods Mentioned

BETA
reverse
transfection
flow cytometry
immunoprecipitation
FACS
xenograft
xenografts
co-immunoprecipitation
Assay
electrophoresis

Software Mentioned

TargetScan
ModFitLT
Agilent Gene Spring
SPSS

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