A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

Dalton Transactions : an International Journal of Inorganic Chemistry
Francesco OliveroLeonardo Marchese

Abstract

A novel luminescent polyhedral oligomeric silsesquioxane (POSS) containing in the structure a fluorescein derivative molecule and a carboxylic functionality, suitable to anchor different organic compounds (dyes, markers, drugs, contrast agents, …), was successfully synthesized and characterized in this manuscript by a multidisciplinary approach. An emission enhancement of the dye of ca. four times was found after reaction with POSS, rendering this new hybrid compound a promising contrast agent for optical imaging. In vitro tests on tumoral HeLa cells demonstrated that the luminescent POSS (namely POSS_F), here described, is able to be taken up in the cell cytosol by an efficient and selective process. Its high chemical versatility and peculiar properties could render this novel bifunctional POSS a molecular platform for biomedical applications.

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Citations

Nov 9, 2012·Inorganic Chemistry·Thapakorn JaroentomeechaiVuthichai Ervithayasuporn
Jan 11, 2013·Organic & Biomolecular Chemistry·Sebastian FabritzHarald Kolmar
Jul 22, 2017·Inorganic Chemistry·Joanna KaźmierczakGrzegorz Hreczycho
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Helene StrauchHermann A Mayer
Dec 20, 2012·Organic & Biomolecular Chemistry·Sebastian HörnerHarald Kolmar
Mar 25, 2016·Chemistry : a European Journal·Shuai-Yuan HanWen-Bin Zhang
Jan 25, 2014·Chemistry : a European Journal·Xiaofan ChenHuanrong Li
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo SianoJuan L Vivero-Escoto

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