A novel MAP-kinase kinase from Candida albicans

Gene
P SinghA Datta

Abstract

A putative MAP-kinase kinase-encoding gene, CaSTE7, was isolated from Candida albicans by complementation of ste7 and ste11 mutants of the pheromone signal-transduction pathway of Saccharomyces cerevisiae. The nucleotide (nt) sequence revealed an ORF of 1767 nt encoding a putative protein of 589 amino acids (aa). CaSTE7 has a strong homology with MAP-kinase kinase STE7 of S. cerevisiae, the kinase domain having 45% homology with that of STE7. The deduced aa sequence contained all eleven consensus kinase subdomains found in MAP-kinase kinases. It can suppress the mating defect of ste5, ste11, ste7, and fus3 kss1 double mutants, but it cannot bypass the ste12 mutation. CaSTE7 behaves as a hyperactive allele of STE7, suppressing the mating defects of the pheromone signal-transduction pathway by constitutively stimulating STE12, and hence STE12-dependent processes.

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Citations

Sep 5, 1998·Trends in Cell Biology·H D Madhani, G R Fink
Oct 31, 2003·Molecular and Cellular Biology·Richard J BennettAlexander D Johnson
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Subhrajit BiswasAsis Datta
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J KumarA Datta

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