PMID: 11927689Apr 3, 2002Paper

A novel mechanism of response selectivity of neurons in cat visual cortex

The Journal of Physiology
M VolgushevU T Eysel

Abstract

The spiking of cortical neurons critically depends on properties of the afferent stimuli. In the visual cortex, neurons respond selectively to the orientation and direction of movement of an object. The orientation and direction selectivity is improved upon transformation of the membrane potential changes into trains of action potentials. To address the question of whether the transformation of the membrane potential changes into spiking of a cell depends on the stimulus orientation and the direction of movement, we made intracellular recordings from the cat visual cortex in vivo during presentation of moving gratings of different orientations. We found that the relationship between the membrane polarization and the firing rate (input-output transfer function) depended on the stimulus orientation. The input-output transfer function was steepest during responses to the optimal stimulus; membrane depolarization of a given amplitude led to generation of more action potentials when evoked by an optimal stimulus than during non-optimal stimulation. The threshold for the action potential generation did not depend on stimulus orientation, and thus could not account for the observed difference in the transfer function. Oscillations of ...Continue Reading

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Citations

May 16, 2006·Journal of Computational Neuroscience·Barak BlumenfeldMisha Tsodyks
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May 20, 2003·The European Journal of Neuroscience·Maxim VolgushevUlf T Eysel

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