PMID: 9525630Apr 3, 1998Paper

A novel membrane protein is a mouse mammary tumor virus receptor

Journal of Virology
T V GolovkinaS R Ross

Abstract

Mouse mammary tumor virus (MMTV) infects a number of different cell types, including mammary gland and lymphoid cells, in vivo. To identify the cellular receptor for this virus, a mouse cDNA expression library was transfected into Cos-7 monkey kidney cells, and those transfected cells able to bind virus were selected by using antibody against the virus's cell surface envelope protein, gp52. One clone isolated from a library prepared from newborn thymus RNA, called MTVR, was able to confer virus binding to both monkey and human cells; this binding was blocked by anti-MTVR antibody. Moreover, transfection of MTVR into CV1 cells rendered them susceptible to infection by a murine leukemia virus-based retrovirus vector pseudotyped with the MMTV envelope protein. An epitope-tagged MTVR cofractionated with cellular membranes. Coimmunoprecipitation of the MMTV envelope protein and a MTVR-rabbit Fc fusion protein showed that these two proteins bound to each other. The MTVR sequence clone is unique, shows no homology to known membrane proteins, and is transcribed in many tissues.

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Citations

Nov 24, 1999·The Journal of General Virology·M A Sommerfelt
Jan 30, 2007·Nature·Chioma M OkeomaSusan R Ross
Feb 3, 2007·Journal of Virology·Maria Cecilia CourregesSusan R Ross
Nov 25, 2011·The Journal of General Virology·Christine HohenadlStanislav Indik
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·John C RassaSusan R Ross
Jan 21, 2009·Journal of Virology·Chioma M OkeomaSusan R Ross
Jul 31, 2007·Future Microbiology·James S LawsonNoel J Whitaker
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan R RossMaja Bucan
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L BattiniA D Miller
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Morgane Bomsel, Annette Alfsen
Aug 10, 1999·Journal of Virology·F BaribaudH Acha-Orbea
Dec 15, 2017·Microbiology and Molecular Biology Reviews : MMBR·Alex D GreenwoodMaribeth V Eiden
Aug 3, 2005·Cancer Research·Stanislav IndikFrancoise Rouault
Oct 8, 1999·Biochemical and Biophysical Research Communications·M Sakuma-TakagiT Kurihara
Apr 4, 2003·Analytical Biochemistry·Masayuki ShimojimaHiroomi Akashi

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