A novel mesoporous biomaterial for treating dentin hypersensitivity

Journal of Dental Research
Y-C ChiangC-P Lin

Abstract

An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca(2+)-and HPO(4)(2-)ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO(4).2H(2)O precipitation with a depth of 100 microm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect.

References

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Dec 1, 1969·Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan·S Ishikawa
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Feb 1, 2006·Dental Materials Journal·Bor-Shiunn LeeChun-Pin Lin
Mar 21, 2007·Journal of Endodontics·Tien-Chun KuoChun-Pin Lin

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Citations

Jul 10, 2014·ISRN Dentistry·E TaliotiD G Gillam
Feb 11, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Chih ChiangChun-Pin Lin
Jul 6, 2011·Dental Clinics of North America·Richard D Trushkowsky, Anabella Oquendo
Apr 23, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Alessandro PoliniAntoni P Tomsia
Mar 31, 2012·Archives of Oral Biology·M G GandolfiC Prati
Jul 22, 2016·Stomatologii︠a︡·M M Uhanov, A N Ryahovsky
May 1, 2018·Microscopy Research and Technique·Serdar BaglarMustafa Turkoz
Nov 19, 2013·Materials·Wen-Cheng ChenChi-Sheng Chien
Oct 23, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qinfeng DingKaili Lin
Dec 9, 2014·ACS Nano·Yu-Chih ChiangChun-Pin Lin
Apr 9, 2018·ACS Biomaterials Science & Engineering·Xin LiLijian Jin

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Methods Mentioned

BETA
x-ray spectroscopy

Software Mentioned

analySiSR

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