PMID: 11507171Aug 17, 2001

A novel method for controlled and reversible long term compression of the umbilical cord in fetal sheep

The Journal of Physiology
D S GardnerD A Giussani


1. In fetal sheep during late gestation the aims of the present study were to (1) develop a technique for inducing prolonged but reversible periods of controlled compression of the umbilical cord and (2) characterise the cardiovascular, endocrine and metabolic responses to this challenge. 2. Under 1-2 % halothane anaesthesia, 16 Welsh Mountain sheep fetuses were chronically instrumented at 118 +/- 2 days of gestation (term is ca 145 days) with an inflatable occluder cuff around the umbilical cord, amniotic and femoral vascular catheters and with transit-time flow probes around the contra-lateral femoral artery and an umbilical artery. At 125 days, umbilical blood flow was reduced by 30 % from a pre-determined 24 h baseline for 3 days by automated servo-controlled inflation of the occluder cuff (n = 8). The occluder was then deflated allowing return of umbilical blood flow to baseline. The remaining eight fetuses were used as sham-operated controls in which the occluder was not inflated throughout the protocol. Fetal cardiovascular variables were recorded at 8 s intervals and arterial blood samples taken for measurement of blood gases, glucose and lactate and plasma adrenaline, noradrenaline and vasopressin concentration through...Continue Reading


Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hobe J Schröder
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May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
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Apr 10, 2004·The Journal of Physiology·D S GardnerD A Giussani
Apr 2, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D S GardnerA L Fowden


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