A novel method for evaluating the effect of pollution on the human skin under controlled conditions

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Seerooven CurpenReshma D Ramracheya

Abstract

Generally considered as a major risk factor for various respiratory diseases, air pollution can also have a significant impact on the skin. To date, there is a plethora of cosmetics products with "anti-pollution" claims. However, these claims have not been fully substantiated with robust scientific evidence and currently there is no standardized method in place for validating the anti-pollution efficacy of cosmetics products. This article discusses an innovative Controlled Pollution Exposure System (CPES) which allows quantified administration of pollutants on the skin and analysis of their direct impact. Using CPES, human subjects were exposed to ambient dust and ozone and sebum were sampled and analyzed for biomarkers. Following exposure of human subjects' skin to either ambient dust(100-450 μg/cm3 ) or ozone(100-1000 ppb), analysis of sebum revealed a significant decrease in squalene concentration, and significant increases in squalene monohydroperoxide and malondialdehyde concentration. The findings demonstrate cutaneous oxidative stress induced by ambient dust and ozone. The findings also demonstrate the efficacy of CPES to accurately measure the direct effect of controlled gaseous and particulate pollutants on human skin ...Continue Reading

References

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Citations

Nov 1, 2020·Journal of Exposure Science & Environmental Epidemiology·Benedetta PetraccaMarc Eeman
Mar 28, 2021·The Science of the Total Environment·Ayesha AslamMohammed Zwawi
Dec 19, 2020·Environmental Science & Technology·Glenn C MorrisonJordan E Krechmer
Nov 11, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Annette DalrympleGeorge Hardie

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