A novel method for lateral callus distraction and its importance for the mechano-biology of bone formation

Bone
L ClaesA Ignatius

Abstract

We introduce a novel method of lateral callus distraction for bone formation, which avoids the conventional splitting and weakening of bones. At the medial aspect of the sheep tibia the periosteum was resected and small holes were drilled into the cortex to connect the bone surface with the marrow. A distraction device with a hydroxyapatite-coated titanium plate was fixed over the drilled area. After 10 days latency the plate was distracted perpendicular to the bone's long axis twice a day by 0.27 mm for 10 days. The newly formed tissue was then allowed 50 days of maturation. In a control group the plate was fixed 5.4mm distant from the bone surface. After 70 days all sheep were sacrificed and investigated histo-morphologically and with pQCT. Significantly more bone had developed between the lateral bone surface and the plate in the distraction group compared to the control group. There was exclusively intra-membranous bone formation with trabeculae oriented in the direction of the applied distraction. The main calcification occurred weeks after the last distraction. In conventional callus distraction the tissue strain caused by distraction is superimposed by the tissue deformation due to the deformation of the fixation device....Continue Reading

References

Mar 1, 1979·Clinical Orthopaedics and Related Research·J C LeongA C Yau
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·O HolbeinL Claes
Jan 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C Neidlinger-WilkeL Claes
Mar 4, 2000·The Journal of Bone and Joint Surgery. British Volume·L ClaesL Kinzl
Sep 19, 2003·Langenbeck's Archives of Surgery·Georg N DudaNorbert P Haas
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Peter AugatLutz Claes
Dec 20, 2005·Bone·Devakara R EpariGeorg N Duda

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Citations

Jul 29, 2011·Revue de stomatologie et de chirurgie maxillo-faciale·T SchoumanG Dubois
Jun 4, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nikola SaulacicPaolo Scolozzi
Oct 6, 2012·Journal of Biomechanics·E Reina-RomoJ M García-Aznar
May 26, 2016·Strategies in Trauma and Limb Reconstruction·Konstantin HorasUwe Horas
Oct 4, 2016·Injury·Esperanza Macarena López-PliegoJaime Domínguez
Mar 16, 2018·PloS One·Frank NiemeyerUlrich Simon
Dec 6, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·A T BachmeierP H Thaller

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