A novel method for long-lasting preservation of arterial grafts
Abstract
Autologous venous grafts generally give best results for arterial bypass grafting in cases of arterial stenosis. When no suitable venous graft can be found, synthetic prosthetic graft may be an alternative. Prostheses are easily accessible but susceptible to infection. In these cases, the replacement of infected prosthesis by the human arterial allograft is the best treatment option. The question arises whether we could prepare a graft meeting mechanical conditions of an artery immunologically inert and resistant to bacterial infection. LEW and BN rat aortic segments were placed in dehydrated sodium chloride and stored for 1 to 12 mo. Then, they were transplanted orthotopically as aortic grafts for 3 to 15 mo in syngenic and allogenic combination. No immunosuppression was used. Patency, pulsation, and frequency of development of aneurysms were studied. The tensile strength and maximum intraluminal pressures were measured. Morphology of grafts was evaluated on histology and electron microscopy. The endothelial and infiltrating cells were identified. Transplanted allogeneic aortic grafts preserved in anhydrous sodium chloride up to 12 mo remained patent for 15 mo. Hypertrophy of intima with endothelial cells lining the inner surf...Continue Reading
References
Function of cryopreserved arterial allografts under immunosuppressive protection with cyclosporine A
Complete loss of functional smooth muscle cells precedes vascular remodeling in rat aorta allografts
Glutaraldehyde treatment of allograft tissue decreases allosensitization after the Norwood procedure
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