A novel method for measuring hollow fiber membrane permeability in a gas-liquid system

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
L W LundB G Hattler

Abstract

Designing an effective intravenous membrane oxygenator requires selecting hollow fiber membranes (HFMs) that present minimal resistance to gas exchange over extended periods of time. Microporous fiber membranes, as used in extracorporeal oxygenators, offer a minimal exchange resistance, but one that diminishes with time because of fiber wetting and subsequent serum leakage. Potentially attractive alternatives are composite HFMs, which inhibit fiber wetting and serum leakage by incorporating a true membrane layer within their porous walls. To evaluate composite and other HFMs, the authors developed a simple apparatus and method for measuring HFM permeability in a gas-liquid system under conditions relevant to intravenous oxygenation. The system requires only a small volume of liquid that is mixed with a pitched blade impeller driven by a direct current motor at controlled rates. Mass flux is measured from the gas flow exiting the fibers, eliminating the necessity of measuring any liquid side conditions. The authors measured the CO2 exchange permeabilities of Mitsubishi MHF 200L composite HFMs, KPF 280E microporous HFMs, and KPF 190 microporous HFMs. The membrane permeabilities to CO2 were 9.3 x 10(-5) ml/cm2/sec/cmHg for the MHF...Continue Reading

Citations

Apr 15, 2006·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Gi-Beum KimChul-Un Hung
Apr 1, 1999·Biotechnology and Bioengineering·S J ErgasJ J Neemann
Aug 24, 1999·Perfusion·B G Hattler, W J Federspiel

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