A novel method for recording neuronal depolarization with recording at 125-825 Hz: implications for imaging fast neural activity in the brain with electrical impedance tomography.

Medical & Biological Engineering & Computing
T OhD S Holder

Abstract

Electrical impedance tomography (EIT) is a recently developed medical imaging method which has the potential to produce images of fast neuronal depolarization in the brain. Previous modelling suggested that applied current needed to be below 100 Hz but the signal-to-noise ratio (SNR) recorded with scalp electrodes during evoked responses was too low to permit imaging. A novel method in which contemporaneous evoked potentials are subtracted is presented with current applied at 225 Hz to cerebral cortex during evoked activity; although the signal is smaller than at DC by about 10×, the principal noise from the EEG is reduced by about 1000×, resulting in an improved SNR. It was validated with recording of compound action potentials in crab walking leg nerve where peak changes of -0.2% at 125 and 175 Hz tallied with biophysical modelling. In recording from rat cerebral cortex during somatosensory evoked responses, peak impedance decreases of -0.07 ± 0.006% (mean ± SE) with a SNR of >50 could be recorded at 225 Hz. This method provides a reproducible and artefact free means for recording resistance changes during neuronal activity which could form the basis for imaging fast neural activity in the brain.

References

Feb 1, 1992·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D S Holder
Aug 1, 1989·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D S Holder
Jan 1, 1988·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D S Holder, A R Gardner-Medwin
Jan 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·B H Brown, A D Seagar
May 1, 1968·Currents in Modern Biology·R VellutiR Galambos
Jul 1, 1968·Journal of Neurophysiology·K A Klivington, R Galambos
Oct 1, 1968·Experimental Neurology·R Galambos, R Velluti
Apr 11, 1996·Nature·P MetherallB H Brown
Apr 13, 2001·Current Opinion in Neurobiology·A M Dale, E Halgren
Jun 1, 1955·Journal of Cellular Physiology·W H FREYGANG, W M LANDAU
Feb 1, 1963·Experimental Neurology·J B RANCK
May 9, 2006·Magnetic Resonance Imaging·Gisela E HagbergBruno Maraviglia
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laura M ParkesDavid G Norris
Jun 29, 2007·Medical & Biological Engineering & Computing·O GiladD S Holder
Jul 14, 1967·Science·K A Klivington, R Galambos
Jun 6, 2009·Physiological Measurement·L FabriziD S Holder
Jul 8, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Adam Gibson, Hamid Dehghani
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ryota HommaDejan Zecevic
May 20, 1939·The Journal of General Physiology·K S Cole, H J Curtis
Nov 17, 2009·Journal of Physiology, Paris·S Chemla, F Chavane

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Citations

Apr 23, 2011·Medical & Biological Engineering & Computing·Selma Supek, Ratko Magjarevic
Aug 14, 2012·Journal of Neurosurgery. Pediatrics·Sukhraaj BasatiAndreas Linninger
Sep 9, 2015·NeuroImage·Kirill Y AristovichDavid S Holder
Oct 16, 2016·Medical & Biological Engineering & Computing·Stefan CandefjordMikael Persson
Jun 1, 2017·Journal of Physiology, Paris·Alexandre FouchardOlivier David
Dec 25, 2013·The Journal of International Medical Research·Bin YangXiuzhen Dong
Mar 30, 2017·Physiological Measurement·Mayo FaulknerDavid Holder
Mar 7, 2019·Physiological Measurement·Sana HannanDavid Holder
Jun 27, 2019·Journal of Neural Engineering·Ilya TarotinDavid Holder
Jul 13, 2016·Physics in Medicine and Biology·Yizhuang SongJin Keun Seo
Mar 3, 2018·NeuroImage·Anna Witkowska-WrobelDavid Holder

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