A novel method for the analysis of clinical biomarkers to investigate the effect of diet on health in a rat model

The Analyst
K HopesC Turner

Abstract

Experiments into the relationship between diet and health have been an area of high interest for a long time. In this study, we investigate the application of multivariate data analysis to differentiate between rat populations fed on two different diets: normal rat diet (control) and Western affluent diet (WAD). Two sets of data were acquired and analysed: one from a biochemical clinical analyser, taking measurements of blood-based biochemical markers; the other from the analysis of the volatile organic compounds (VOCs) emitted from faecal samples from the same animals using selected ion flow tube mass spectrometry (SIFT-MS). Five classes were considered: weanlings, 12 month controls, 12 month WADs, 18 month controls, and 18 month WADs. Data from the biochemical analyser, weanlings and 18 month WAD fed rats showed significant differences from the other measurement classes. This was shown in both the exploratory analysis and through multivariate classification. Classification of control diet versus WAD diets suggested there are differences between classes with 92% accuracy for the 12 month classes and 91% for the 18 month classes. Cholesterol markers, especially as low density lipoprotein-cholesterol (LDL), were the main factor ...Continue Reading

References

Oct 1, 1979·The Journal of Clinical Investigation·S V ShahT P Dousa
Jan 1, 1976·Acta Pharmacologica Et Toxicologica·H Marchner, O Tottmar
Dec 29, 1999·The Journal of Nutrition·W H Hendriks, S Wamberg
Nov 12, 2003·Hypertension·Feng J He, Graham A MacGregor
Jan 24, 2004·Journal of Experimental Botany·Ross M Welch, Robin D Graham
Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michal Carmiel-HaggaiNatalia Nieto
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Mar 15, 2005·Clinics in Liver Disease·Charles S Lieber
Jun 10, 2006·BMC Genomics·Robert A van den BergMariët J van der Werf
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
May 15, 2007·The New England Journal of Medicine·Horacio J Adrogué, Nicolaos E Madias
Feb 5, 2008·Nutrition Reviews·Simin Nikbin Meydani, Dayong Wu
Mar 27, 2010·Journal of the American College of Nutrition·D Craig WillcoxMakoto Suzuki
Mar 27, 2010·Journal of Proteome Research·Kishore Kumar PasikantiEric Chun Yong Chan
Jul 22, 2010·Mass Spectrometry Reviews·Patrik Spaněl, David Smith
Jun 17, 2011·Nature·Andrew L KauJeffrey I Gordon
Jun 29, 2011·Expert Review of Molecular Diagnostics·Claire Turner
Mar 2, 2013·Current Pharmaceutical Design·Maarten Hulsmans, Paul Holvoet
Jul 23, 2013·Inflammatory Bowel Diseases·Christopher WaltonJohn O Hunter
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe

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