PMID: 11923058Mar 30, 2002Paper

A novel method of producing a microcrystalline beta-sitosterol suspension in oil

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
L ChristiansenJ Yliruusi

Abstract

This paper describes a novel method of producing a microcrystalline oral suspension containing beta-sitosterol in oil for the treatment of hypercholesterolaemia. beta-Sitosterol pseudopolymorphs with different water contents were crystallized from acetone and acetone-water solutions. Structural analyses of the crystals were performed by Karl-Fisher titration, thermogravimetric analyses, X-ray diffraction and near infrared spectroscopy. The suspensions studied were composed of different concentrations of beta-sitosterol, oil and water. Suspensions were prepared by crystallization of hot concentrated solution of beta-sitosterol in oil by cooling with simultaneous agitation and water addition. The structural analyses of the suspensions were performed by X-ray diffraction, near infrared spectroscopy and optical microscopy. The viscosity of the suspensions was analysed as a function of shear stress. beta-Sitosterol was observed to exist in three different forms: anhydrous, hemihydrated and monohydrated crystals. By changing both the beta-sitosterol and the water concentration of the suspension, the crystal size and shape could be controlled. Addition of water resulted in the formation of monohydrated needle-shaped crystals instead o...Continue Reading

References

Jul 1, 1977·The Journal of Nutrition·F H MattsonB A Erickson
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Citations

Mar 8, 2003·International Journal of Pharmaceutics·L ChristiansenJ Yliruusi
Jul 30, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Anna von Bonsdorff-NikanderJouko Yliruusi
Dec 16, 2005·AAPS PharmSciTech·Anna von Bonsdorff-NikanderJouko Yliruusi
Nov 19, 2003·AAPS PharmSciTech·Anna von Bonsdorff-NikanderJouko Yliruusi
Nov 25, 2006·Bioresource Technology·P Fernandes, J M S Cabral
Aug 2, 2016·Journal of Agricultural and Food Chemistry·Lisa M ZychowskiMark A E Auty
Aug 24, 2016·Food & Function·Wen-Jun CaoChuan-He Tang
Oct 27, 2016·Physical Chemistry Chemical Physics : PCCP·Carien C M GrootHuib J Bakker
Jun 28, 2017·Journal of the Science of Food and Agriculture·Dan-Xia YangXiao-Quan Yang
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva DaelsBart Goderis
Jun 15, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Russell MacoonAnuj Chauhan
Feb 14, 2007·Journal of Agricultural and Food Chemistry·Hariklia VaikousiJerzy Zawistowski

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