A novel microRNA miR-1165-3p as a potential diagnostic biomarker for allergic asthma

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Chaojie WuMingshun Zhang

Abstract

A further examination of a novel miRNA,miR-1165-3p as a biomarker for asthma, which was previously implicated in helper T cells (Th2) in a murine asthma model. To determine whether serum miR-1165-3p can serve as a potential diagnostic biomarker for allergic asthma. Serum miR-1165-3p was quantified via quantitative real-time PCR (qRT-PCR) in asthmatic and control samples. Serum miR-1165-3p levels were compared between groups and the clinical diagnostic abilities of miR-1165-3p were evaluated. The analyses utilized included a student's t test, one-way ANOVA, and the generation of receiver operating characteristic (ROC) curves. Serum miRNA-1165-3p levels were significantly elevated in asthmatics when compared to the healthy controls. Furthermore, the sensitivity and specificity of serum miR-1165-3p were found to be 83% and 68.2%. Additionally, serum miR-1165-3p levels were also found to be significantly elevated in patients with allergic rhinitis (AR) or allergic bronchopulmonary aspergillosis (ABPA). This study showed that serum miR-1165-3p can potentially be utilized as a noninvasive biomarker that is able to aid in the diagnosis and characterization of allergic asthma.

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Citations

Nov 15, 2019·Clinical Microbiology Reviews·Jean-Paul Latgé, Georgios Chamilos
Sep 5, 2019·American Journal of Physiology. Cell Physiology·Sébastien BonnetShizuka Uchida
Nov 1, 2020·Allergy·Julie WeidnerMadeleine Rådinger
Dec 29, 2020·Therapeutic Advances in Respiratory Disease·Li XuYuan Zhang
Jun 3, 2021·Genes·Sanja Popović-GrleDina Rnjak
Aug 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMarek Sanak

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