A novel microwave sensor for real-time online monitoring of roll compacts of pharmaceutical powders online--a comparative case study with NIR

Journal of Pharmaceutical Sciences
Anshu GuptaGintaras Reklaitis

Abstract

Control of particulate processes is hard to achieve because of the ease with which powders tend to segregate. Thus, proper sensing methods must be employed to ensure content uniformity during operation. The role of sensing schemes becomes even more critical while operating the process continuously as measurements are essential for implementation of feedback control (Austin et al. 2013. J Pharm Sci 102(6):1895-1904; Austin et al. 2014. Anal Chim Acta 819:82-93). A microwave sensor was developed and shown to be effective in online measurement of active pharmaceutical ingredient (API) concentration in a powder blend. During powder transport and hopper storage before processing, powder blends may segregate and cause quality deviations in the subsequent tableting operation. Therefore, it is critical to know the API concentration in the ribbons as the content uniformity is fixed once the ribbon is processed. In this study, a novel microwave sensor was developed that could provide measurement of a roller compacted ribbon's API concentration online, along with its density and moisture content. The results indicate that this microwave sensor is capable of increased accuracy compared with a commercially available near-IR probe for the de...Continue Reading

References

Nov 3, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Caroline BuschmüllerJörg Breitkreutz
Dec 21, 2010·International Journal of Pharmaceutics·T De BeerC Vervaet
Feb 22, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vera LourençoDirk Lochmann
Apr 10, 2013·Journal of Pharmaceutical Sciences·John AustinMichael T Harris
Mar 19, 2014·Analytica Chimica Acta·John AustinMichael T Harris

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Citations

May 16, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Aleša Dular Vovko, Franc Vrečer

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