A novel mitochondria-targeted ratiometric fluorescent probe for endogenous sulfur dioxide derivatives as a cancer-detecting tool.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Di YangZhao-Min Lin

Abstract

A new mitochondria-targeted fluorescent probe RBC, constructed using a coumarin moiety which was selected as the donor and a benzothiazole derivative as the acceptor, for SO2 derivatives (HSO3-/SO32-) was presented. The probe designed on a new FRET platform showed high selectivity and a low detection limit. Importantly, the probe could respond to HSO3-/SO32- within 35 s. Furthermore, the probe could target mitochondria and was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 with low cytotoxicity, which significantly assisted in cancer diagnosis.

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Citations

Jan 6, 2021·Journal of Fluorescence·Jianbin ChaoYuexiang Duan
Aug 3, 2021·Journal of Fluorescence·Wenjie LiuMingming Yu

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Methods Mentioned

BETA
FRET
column chromatography
Fluorescence
the
confocal microscopy
fluorescence imaging

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